3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE

Base Information

• Chemical Name: 3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE
• CAS No.: 50709-88-1
• Molecular Formula: C15H10ClNO2S
• Molecular Weight: 303.769
• Hs Code.: 2926909090
• Mol file: 50709-88-1.mol

Synonyms:3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE

Chemical Property of 3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE

Chemical Property:

• Vapor Pressure: 7.35E-11mmHg at 25°C
• Melting Point: 152-154°C
• Refractive Index: 1.627
• Boiling Point: 518.6°C at 760 mmHg
• Flash Point: 267.5°C
• PSA: 66.31000
• Density: 1.37g/cm³
• LogP: 4.75918

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Chlorophenyl)-2-(phenylsulfonyl)acrylonitrile >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE

There total 3 articles about 3-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ACRYLONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chlorobenzaldehyde (104-88-1) + 2-(phenylsulfonyl)acetonitrile (7605-28-9) → 3-(4-chlorophenyl)-2-phenylsulfonyl-2-propenenitrile (50709-88-1)

Guidance literature:

With mesoporous Al-MCM-41 functionalized by layered double hydroxide nanosheets and (3-aminopropyl)triethoxysilane; In ethanol; at 80 ℃; for 2h; Solvent; Reagent/catalyst; Schlenk technique;

DOI:10.1007/s10562-019-03089-8

Reference yield: 85.0%

sodium benzenesulfonate (873-55-2) + 4-chlorobenzaldehyde (104-88-1) + chloroacetonitrile (107-14-2) → 3-(4-chlorophenyl)-2-phenylsulfonyl-2-propenenitrile (50709-88-1)

Guidance literature:

With 1-butyl-3-methylimidazolium hydroxide; In ethanol; for 6h; Solvent; Time; Reagent/catalyst; Reflux; Green chemistry;

DOI:10.1016/j.cclet.2012.10.013

Reference yield:

sodium benzenesulfonate (873-55-2) → 3-(4-chlorophenyl)-2-phenylsulfonyl-2-propenenitrile (50709-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide

2: piperidine / benzene; dimethylformamide

With piperidine; In N,N-dimethyl-formamide; benzene;

upstream raw materials:

4-chlorobenzaldehyde

2-(phenylsulfonyl)acetonitrile

sodium benzenesulfonate

chloroacetonitrile

Downstream raw materials:

(2E)-3-(4-chlorophenyl)acrylonitrile

3-(4-chlorophenyl)propanenitrile

2-(4-chloro-phenyl)-4-imino-9,10-dimethoxy-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonitrile

(+)-ethyl 2-(2R-cyano-4S-nitro-3R-(4-chlorophenyl)-2R-(phenylsulfonyl)-1S-cyclohexyl)acetate