2-AMINO-5-CHLORO-NICOTINIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-AMINO-5-CHLORO-NICOTINIC ACID METHYL ESTER
• CAS No.: 50735-33-6
• Molecular Formula: C7H7ClN2O2
• Molecular Weight: 186.59568
• Hs Code.: 2933399090
• Mol file: 50735-33-6.mol

Synonyms:2-AMINO-5-CHLORO-NICOTINIC ACID METHYL ESTER

Chemical Property of 2-AMINO-5-CHLORO-NICOTINIC ACID METHYL ESTER

Chemical Property:

• PSA: 65.21000
• LogP: 1.68500
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-amino-5-chloropyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-CHLORO-NICOTINIC ACID METHYL ESTER

There total 4 articles about 2-AMINO-5-CHLORO-NICOTINIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 2-aminonicotinate (14667-47-1) → methyl 2-amino-5-chloro-3-pyridinecarboxylate (50735-33-6)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 60 ℃; for 6h; Concentration; Temperature; Solvent;

Reference yield: 75.0%

methyl 2,5-dichloronicotinate (67754-03-4) → methyl 2-amino-5-chloro-3-pyridinecarboxylate (50735-33-6)

Guidance literature:

With ammonia; water; In 1,4-dioxane; at 80 - 90 ℃; for 216h;

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) → methyl 2-amino-5-chloro-3-pyridinecarboxylate (50735-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.2 g / K₂CO₃ / dimethylformamide / 18 h

2: 26 percent / HCl(gas); tert-butylhypochlorite / methanol

With hydrogenchloride; tert-butylhypochlorite; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0509501

upstream raw materials:

methyl 2-aminonicotinate

2-aminopyridin-3-carboxylic acid

methyl 2,5-dichloronicotinate

Downstream raw materials:

SC 53606

methyl 6-chloroimidazol[1,2-a]pyridine-8-carboxylate