2,2-DIMETHYLPROPIONAMIDINE

Base Information

• Chemical Name: 2,2-DIMETHYLPROPIONAMIDINE
• CAS No.: 59950-56-0
• Molecular Formula: C5H12N2
• Molecular Weight: 100.164
• Hs Code.: 2925290090
• Mol file: 59950-56-0.mol

Synonyms:SPECS AG-690/33428046;2,2-DIMETHYLPROPIONAMIDINE

Chemical Property of 2,2-DIMETHYLPROPIONAMIDINE

Chemical Property:

• Boiling Point: 126.9±23.0 °C(Predicted)
• PKA: 12.87±0.40(Predicted)
• PSA: 49.87000
• Density: 0.92±0.1 g/cm3(Predicted)
• LogP: 1.76850

Purity/Quality:

98%min ^*data from raw suppliers

2,2-Dimethylpropionimidine 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYLPROPIONAMIDINE

There total 4 articles about 2,2-DIMETHYLPROPIONAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,2-dimethyl-propionimidic acid ethyl ester (52186-79-5) → pivalimidamide (59950-56-0)

Guidance literature:

With ammonia; In ethanol; at 20 ℃; for 3h;

Reference yield: 76.0%

ethyl 2,2-dimethylpropanimidoate hydrochloride (58910-26-2) → pivalimidamide (59950-56-0)

Guidance literature:

With ammonia; In ethanol; at 20 ℃; for 3h;

Reference yield:

tert-butyl isocyanide (630-18-2) → pivalimidamide (59950-56-0)

Guidance literature:

With sodium amide; triethylamine; for 45h;

DOI:10.1007/s00706-015-1515-7

upstream raw materials:

2,2-dimethyl-propionimidic acid ethyl ester

ethyl 2,2-dimethylpropanimidoate hydrochloride

tert-butyl isocyanide

Downstream raw materials:

2-t-butyl-3,4-dihydro-4-oxopyrimidine

C₂₂H₂₀N₂O

2-tert-butyl-1H-benzimidazole

2,2-dimethyl-N-phenylpropionamidine

Refernces

• 1、 -. "Heterocyclic Compounds Useful as RAF Kinase Inhibitors". Page/Page column 45. . Retrieved 2009/01/24.