4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-(1-methylethyl)-(9CI)

Base Information

• Chemical Name: 4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-(1-methylethyl)-(9CI)
• CAS No.: 500161-23-9
• Molecular Formula: C7H11N3O2
• Molecular Weight: 169.18
• Hs Code.: 2933599590
• Mol file: 500161-23-9.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-(1-methylethyl)-(9CI);4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-(1-methylethyl)-

Chemical Property of 4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-(1-methylethyl)-(9CI)

Chemical Property:

• Vapor Pressure: 5E-08mmHg at 25°C
• Refractive Index: 1.631
• Boiling Point: 430.8°C at 760 mmHg
• PKA: 7.72±0.10(Predicted)
• Flash Point: 214.4°C
• PSA: 92.26000
• Density: 1.352g/cm³
• LogP: 0.35960

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-AMINO-4,6-DIHYDROXY-5-ISOPROPYLPYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-(1-methylethyl)-(9CI)

There total 2 articles about 4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-(1-methylethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diethyl isopropylmalonate (759-36-4) + guanidine hydrochloride (50-01-1) → 2-amino-5-isopropylpyrimidine-4,6-diol (500161-23-9)

Guidance literature:

diethyl isopropylmalonate; guanidine hydrochloride; With sodium; In ethanol; at 20 ℃; for 4h; Inert atmosphere;

In ethanol; for 1h; Inert atmosphere; Reflux;

DOI:10.1007/s00044-014-1018-9

Reference yield: 93.0%

→ 2-amino-5-isopropylpyrimidine-4,6-diol (500161-23-9)

Guidance literature:

Reference yield:

2-amino-5-isopropylpyrimidine-4,6-diol (500161-23-9) → 4,6-dichloro-5-isopropylpyrimidin-2-amine (500161-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform / 4 h / Inert atmosphere; Reflux

2: hydrogenchloride / water; ethanol / 2 h / 50 °C

With hydrogenchloride; In ethanol; chloroform; water;

DOI:10.1007/s00044-014-1018-9

upstream raw materials:

diethyl isopropylmalonate

guanidine hydrochloride

Downstream raw materials:

4,6-dichloro-5-isopropylpyrimidin-2-amine