5-(3,4-Difluorophenyl)furan-2-carboxylic acid

Base Information

Chemical Name:5-(3,4-Difluorophenyl)furan-2-carboxylic acid
CAS No.:55377-81-6
Molecular Formula:C11H6F2O3
Molecular Weight:224.16
Hs Code.:
DSSTox Substance ID:DTXSID80547827
Wikidata:Q82426309
Mol file:55377-81-6.mol

Synonyms:55377-81-6;5-(3,4-difluorophenyl)furan-2-carboxylic acid;5-(3,4-DIFLUOROPHENYL)-FURAN-2-CARBOXYLIC ACID;SCHEMBL3731167;DTXSID80547827

Suppliers and Price of 5-(3,4-Difluorophenyl)furan-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 5-(3,4-Difluorophenyl)furan-2-carboxylic acid

Chemical Property:

PSA：50.44000
LogP:2.92300
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:224.02850037
Heavy Atom Count:16
Complexity:272

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C2=CC=C(O2)C(=O)O)F)F

Technology Process of 5-(3,4-Difluorophenyl)furan-2-carboxylic acid

There total 4 articles about 5-(3,4-Difluorophenyl)furan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 55377-80-5
5-(3,4-difluorophenyl)furan-2-carbaldehyde

: 55377-81-6
5-(3,4-difluorophenyl)furan-2-carboxylic acid

Guidance literature:: With sodium hydroxide; silver nitrate; Ambient temperature;
DOI:10.1002/jps.2600690135

Reference yield:

: C₁₂H₈F₂O₃

: 55377-81-6
5-(3,4-difluorophenyl)furan-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2018.12.058

Reference yield:

: 168267-41-2
(3,4-difluorophenyl)boronic acid

: 55377-81-6
5-(3,4-difluorophenyl)furan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 5 h / 100 °C

2: sodium hydroxide / methanol / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2018.12.058