2H-Cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione, 1,5-dihydro-1,3-dimethyl- (9CI)

Base Information

• Chemical Name: 2H-Cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione, 1,5-dihydro-1,3-dimethyl- (9CI)
• CAS No.: 548475-54-3
• Molecular Formula: C13H12N2O3
• Molecular Weight: 244.25
• Mol file: 548475-54-3.mol

Synonyms:2H-Cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione, 1,5-dihydro-1,3-dimethyl- (9CI)

Chemical Property of 2H-Cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione, 1,5-dihydro-1,3-dimethyl- (9CI)

Chemical Property:

• PSA: 57.14000
• LogP: 0.95570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione, 1,5-dihydro-1,3-dimethyl- (9CI)

There total 3 articles about 2H-Cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione, 1,5-dihydro-1,3-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5,5-bis-(1,3-dimethyl-2,4-dioxo-1,3,4,7-tetrahydro-2H-10-oxa-1,3-diaza-benzo[a]azulen-7-yl)-1,3-dimethyl-pyrimidine-2,4,6-trione → 7,9-dimethyl-1H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-54-3) + 7,9-dimethyl-5H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-56-5) + 7,9-dimethyl-3H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-55-4) + 7,9-dimethyl-3-[1',3'-dimethyl-2'(1'H),4'(3'H),6'(5'H)-trioxopyrimidin-5'-ylidene]cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (734076-02-9)

Guidance literature:

In xylene; at 90 ℃; for 3h;

DOI:10.1021/jo049668c

Reference yield: 38.0%

1,3-dimethylbarbituric acid (769-42-6) + 2-methoxytropone (2161-40-2) → 7,9-dimethyl-1H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-54-3) + 7,9-dimethyl-5H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-56-5) + 7,9-dimethyl-3H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-55-4) + 7,9-dimethyl-3-[1',3'-dimethyl-2'(1'H),4'(3'H),6'(5'H)-trioxopyrimidin-5'-ylidene]cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (734076-02-9)

Guidance literature:

With acetic anhydride; for 0.5h; Heating;

DOI:10.1021/jo049668c

Reference yield:

7,9-dimethylcyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dionylium tetrafluoroborate → 7,9-dimethyl-1H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-54-3) + 7,9-dimethyl-5H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-56-5) + 7,9-dimethyl-3H-cyclohepta[b]pyrimido[5,4-d]furan-8(7H),10(9H)-dione (548475-55-4)

Guidance literature:

With sodium tetrahydroborate; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(03)00118-2

upstream raw materials:

1,3-dimethylbarbituric acid

2-methoxytropone