2161-40-2

Usage

Uses

Given the provided materials, there are no specific applications mentioned for alpha-Methoxytropone. However, its stimulant and dopamine reuptake inhibitory effects suggest potential uses in the following areas:
Used in Pharmaceutical Industry:
Alpha-Methoxytropone could be used as a research compound for developing new medications targeting the dopamine system, potentially for conditions such as Parkinson's disease or attention deficit hyperactivity disorder (ADHD). However, due to its psychoactive properties and potential for abuse, any application in this area would require rigorous testing and regulation.
Used in Research and Development:
Alpha-Methoxytropone may be utilized as a research tool in the study of psychoactive substances, addiction, and the dopamine system. Understanding its effects and mechanisms of action could contribute to the development of safer and more effective treatments for various neurological and psychiatric disorders.

InChI:InChI=1/C8H8O2/c1-10-8-6-4-2-3-5-7(8)9/h2-6H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 124-41-4 sodium methylate 
• 3839-48-3 2-chlorotropone 
• 108279-98-7 2-(2-Thienylmethoxy)tropone 
• 67-56-1 methanol 
• 539-80-0 Tropone 
• 1714-38-1 7-methoxy-1,3,5-cycloheptatriene 
• 115319-04-5 endo-2-Methoxy-8-oxabicyclo<3.2.1>oct-6-en-3-on 
• 72012-54-5 4-methoxy-6,7-dioxabicyclo<3.2.2>nona-2,8-diene 
• 125102-15-0 2-methoxy-5-<<(trifluoromethyl)sulfonyl>oxy>tropone 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 74-83-9 methyl bromide 

Downstream Products

• 100621-68-9 2-o-tolyl-cycloheptatrienone 
• 3480-08-8 2-aminocycloheptimidazole 
• 93-58-3 benzoic acid methyl ester 
• 14562-09-5 2-phenylcyclohepta-2,4,6-triene-1-one 
• 4481-35-0 cyclohepta[b]furan-2(2H)-one 
• 363-67-7 3,5,7-tribromotropolone 
• 40394-02-3 2-(4-methoxyphenyl)-2,4,6-cycloheptatrienone 
• 20764-21-0 7-methoxybicyclo[3.2.0]heptadienone 
• 52065-24-4 1-Methoxy-8.8-diphenylheptafulven 
• 934-19-0 7-oxo-1,3,5-cycloheptatrienecarbonitrile 
• 53526-98-0 2-<2-(m-tolyl)hydrazino>tropone 
• 53526-97-9 2-<2-(o-tolyl)hydrazino>tropone 
• 113397-20-9 (1R,6R)-1,6-Bis-(2-chloro-phenyl)-1,6-diphenyl-hexa-2,4-diyne-1,6-diol; compound with 2-methoxy-cyclohepta-2,4,6-trienone 
• 113397-23-2 Biphenyl-2,2'-dicarboxylic acid bis-dicyclohexylamide; compound with 2-methoxy-cyclohepta-2,4,6-trienone 

Relevant academic research and scientific papers

THE EFFECT ON THE BASE STRENGTHS OF TROPONE AND 2-ALKOXYTROPONES OF ?-COMPLEXATION WITH A Cr(CO)3 GROUP

?-Complexation of tropone and its 2-methoxy and 2-ethoxy derivatives with a Cr(CO)3 group causes an increase in the ketonic base strength by 1.7 +/- 0.3 pK units.

Fungicidal activity of β-thujaplicin analogues

The fungicidal activity of analogues of β-thujaplicin, a natural product responsible for the durability of heartwood of several cupressaceous trees, was investigated in vitro on the growth of different white and brown rot fungi involved in wood biodegradation, Coriolus versicolor, Phanerochaete chrysosporium, Poria placenta and Gloephyllum trabeum. The study shows that 2-hydroxycyclohepta-2,4,6-trienone (tropolone), easily prepared according to a literature procedure, possesses interesting fungicidal activity when compared to β-thujaplicin, azaconazole, tebuconazole and copper oxine, which suggests this compound should be examined further as a potential biocide for wood preservation.

Electrochemical methoxylation of 1,2,3-trisubstituted azulenes

1,2,3-Trisubstituted azulene analogs 6a and 6b easily underwent methoxylation in position 4 or 6 of an azulene ring via an electrochemical oxidation. It is a simple, convenient and selective method for introducing a methoxy group into a 7-membered ring of azulene analogs when compared with traditional chemical methods. It could be useful in preparing 2,4- and 2,6-azuloquinone analogs.

Tropolonyl ethers of saccharides and cyclitol derivatives

Mitsunobu coupling between tropolones and saccharide or cyclitol derivatives featuring primary or secondary alcohol functions provides for the first time an easy, general and efficient access to the corresponding tropolonyl ethers. Selective deprotection of the carbohydrate or cyclitol units demonstrates that naked saccharides and cyclitols bearing a tropolonyl ether moiety may be prepared by this route.

AMBIPHILIC REACTIVITY OF 1,1-DIMETHOXYACETONE

Trialkylsilyloxyallyl cations 2 with a ?-donating methoxy substituent at the allylic termini are generated from nonhalogenated substrates via treatment of 5b-e with Lewis acids. 2 undergoes stereo- and regioselective cycloaddition with furans yielding 2-methoxy-8-oxabicyclooct-6-en-3-ones.Cycloadduct 7 is converted to 2-methoxytropone 14 and thus represents an efficient entry into tropolonoid systems.

HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF

Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.

Protonation behaviour of 2-phenyl-1,3-diazaazulene derivatives

Three 2-phenyl-1,3-diazaazulene derivatives were synthesized and their protonation behaviours were investigated systematically via UV–vis absorption titration and 1H NMR titration, as well as theoretical calculations. One of them exhibited a monoprotonation process while the others displayed prominent halochromic diprotonation responses. Interestingly, upon protonation of 2-phenyl-1,3-diazaazulene derivatives, the coplanarity and conjugation of the 16-π-conjugated backbones were well kept, while the electronic structures were controllably adjusted. The response mechanism of 1,3-diazaazulene derivatives towards acid is through the attachment of acid proton to the nitrogen atom in the diazaazulene ring, resulting in the change of the hybridization of protonated-N from sp2 to sp3, which differed from that of the well-known azulene (analogue of 1,3-diazaazulene, protonation at carbon atom). This work would provide a new insight into the protonation research of the organic functional molecules.

Synthesis, crystal structure and photophysical properties of 1,4-bis(1,3-diazaazulen-2-yl)benzene: A new π building block.

A dimerized 1,3-diazaazulene derivative, namely 1,4-bis(1,3-diazaazulen-2-yl)benzene [or 2,2′-(1,4-phenylene)bis(1,3-diazaazulene)], C22H14N4, (I), has been synthesized successfully through the condensation reaction betwee

Thiocarbonyl Ylide Chemistry Enables a Concise Synthesis of (±)-Hippolachnin A

Hippolachnin A (1) is an antifungal polyketide that bristles with ethyl groups mounted onto a caged heterotricyclic core. It has shown potent activity against Cryptococcus neoformans, a yeast that can affect immunocompromised patients as an opportunistic pathogen. Herein we describe a concise, diversifiable, and scalable synthesis of (±)-hippolachnin A (1). It features a powerful photochemical opening step, a diastereoselective addition of an ethyl cuprate and an unusual strategy to install two additional ethyl groups that makes use of a thiocarbonyl ylide generated in situ.

COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE

There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.