D-Proline, 1-acetyl-4-ethyl-5-hydroxy-, methyl ester (9CI)

Base Information

Chemical Name:D-Proline, 1-acetyl-4-ethyl-5-hydroxy-, methyl ester (9CI)
CAS No.:548490-83-1
Molecular Formula:C10H17NO4
Molecular Weight:215.24628
Hs Code.:
Mol file:548490-83-1.mol

Synonyms:D-Proline, 1-acetyl-4-ethyl-5-hydroxy-, methyl ester (9CI)

Suppliers and Price of D-Proline, 1-acetyl-4-ethyl-5-hydroxy-, methyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of D-Proline, 1-acetyl-4-ethyl-5-hydroxy-, methyl ester (9CI)

Chemical Property:

PSA：66.84000
LogP:0.06270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of D-Proline, 1-acetyl-4-ethyl-5-hydroxy-, methyl ester (9CI)

There total 4 articles about D-Proline, 1-acetyl-4-ethyl-5-hydroxy-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 201230-82-2
carbon monoxide

: 199540-02-8
(2R,4E)-methyl 2-acetamidohex-4-enoate

: 548490-83-1
(2R)-methyl N-acetyl-4-ethyl-5-hydroxyprolinate

: 548490-82-0
(2R)-methyl N-acetyl-5-methyl-6-hydroxypipecolate

Guidance literature:: With hydrogen; triphenylphosphine; dirhodium tetraacetate; In benzene; at 80 ℃; for 20h; under 20686.5 Torr;
DOI:10.1039/b209087m

Reference yield:

: 89524-99-2
methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate

: 548490-83-1
(2R)-methyl N-acetyl-4-ethyl-5-hydroxyprolinate

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / tetramethylguanidine / tetrahydrofuran / -78 - 25 °C

2: H₂ / Rh-(S,S)-Et-DuPHOS / benzene / 2 h / 20 °C / 4654.46 Torr

3: H₂; PPh₃ / rhodium(II) acetate dimer / benzene / 20 h / 80 °C / 20686.5 Torr

With 1,1,3,3-tetramethylguanidine; hydrogen; triphenylphosphine; dirhodium tetraacetate; Rh-(S,S)-Et-DuPHOS; In tetrahydrofuran; benzene; 1: Horner-Emmons olefination;
DOI:10.1039/b209087m

Reference yield:

: 73198-56-8
N-acetyl-α-methoxyglycine methyl ester

: 548490-83-1
(2R)-methyl N-acetyl-4-ethyl-5-hydroxyprolinate

Guidance literature:: Multi-step reaction with 4 steps

1: 30 percent / PCl₃ / 70 °C

2: 55 percent / tetramethylguanidine / tetrahydrofuran / -78 - 25 °C

3: H₂ / Rh-(S,S)-Et-DuPHOS / benzene / 2 h / 20 °C / 4654.46 Torr

4: H₂; PPh₃ / rhodium(II) acetate dimer / benzene / 20 h / 80 °C / 20686.5 Torr

With 1,1,3,3-tetramethylguanidine; hydrogen; triphenylphosphine; phosphorus trichloride; dirhodium tetraacetate; Rh-(S,S)-Et-DuPHOS; In tetrahydrofuran; benzene; 2: Horner-Emmons olefination;
DOI:10.1039/b209087m