2,2,2-Trifluoro-1-(1-azaspiro[4.4]non-7-en-1-yl)ethanone

Base Information

Chemical Name:2,2,2-Trifluoro-1-(1-azaspiro[4.4]non-7-en-1-yl)ethanone
CAS No.:681283-60-3
Molecular Formula:C10H12F3NO
Molecular Weight:219.2035896
Hs Code.:
DSSTox Substance ID:DTXSID00477814
Nikkaji Number:J2.117.195F
Mol file:681283-60-3.mol

Synonyms:681283-60-3;2,2,2-Trifluoro-1-(1-azaspiro[4.4]non-7-en-1-yl)ethanone;1-{1-azaspiro[4.4]non-7-en-1-yl}-2,2,2-trifluoroethan-1-one;1-(1-Azaspiro[4.4]non-7-en-1-yl)-2,2,2-trifluoroethan-1-one;1-Azaspiro[4.4]non-7-ene, 1-(trifluoroacetyl)- (9CI);DTXSID00477814;1-Azaspiro[4.4]non-7-ene,1-(trifluoroacetyl)-(9ci)

Suppliers and Price of 2,2,2-Trifluoro-1-(1-azaspiro[4.4]non-7-en-1-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2,2,2-Trifluoro-1-(1-azaspiro[4.4]non-7-en-1-yl)ethanone

Chemical Property:

PSA：20.31000
LogP:2.19780
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:219.08709849
Heavy Atom Count:15
Complexity:300

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2(CC=CC2)N(C1)C(=O)C(F)(F)F

Technology Process of 2,2,2-Trifluoro-1-(1-azaspiro[4.4]non-7-en-1-yl)ethanone

There total 2 articles about 2,2,2-Trifluoro-1-(1-azaspiro[4.4]non-7-en-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2,2-diallyl-1-(trifluoroacetyl)pyrrolidine

: 681283-60-3
1-(trifluoroacetyl)-1-azaspiro[4.4]non-7-ene

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; at 22 ℃; for 1h;
DOI:10.1002/ejoc.200300373

Reference yield:

: 40162-97-8
2,2-di(2-propenyl)pyrrolidine

: 681283-60-3
1-(trifluoroacetyl)-1-azaspiro[4.4]non-7-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 5 h / 20 °C

2: 91 percent / RuCl₂(=CHPh)(PCy₃)2 / CH₂Cl₂ / 1 h / 22 °C

With dmap; triethylamine; Grubbs catalyst first generation; In dichloromethane;
DOI:10.1002/ejoc.200300373