1-N-BOC-4-(3-CHLOROPHENYL)-4-CYANOPIPERIDINE

Base Information

• Chemical Name: 1-N-BOC-4-(3-CHLOROPHENYL)-4-CYANOPIPERIDINE
• CAS No.: 553631-33-7
• Molecular Formula: C17H21ClN2O2
• Molecular Weight: 320.819
• Hs Code.: 2933399090
• Mol file: 553631-33-7.mol

Synonyms:1-N-BOC-4-(3-CHLOROPHENYL)-4-CYANOPIPERIDINE

Chemical Property of 1-N-BOC-4-(3-CHLOROPHENYL)-4-CYANOPIPERIDINE

Chemical Property:

• PSA: 53.33000
• LogP: 4.07018
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

tert-Butyl 4-(3-chlorophenyl)-4-cyanopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-N-BOC-4-(3-CHLOROPHENYL)-4-CYANOPIPERIDINE

There total 3 articles about 1-N-BOC-4-(3-CHLOROPHENYL)-4-CYANOPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine (118753-70-1) → tert-butyl 4-(3-chlorophenyl)-4-cyanopiperidine-1-carboxylate (553631-33-7)

Guidance literature:

3-chloro-benzeneacetonitrile; With 15-crown-5; sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.583333h;

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine; With sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 70.0%

3-chloro-benzeneacetonitrile (1529-41-5) + N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine (118753-70-1) → tert-butyl 4-(3-chlorophenyl)-4-cyanopiperidine-1-carboxylate (553631-33-7)

Guidance literature:

With 18-crown-6 ether; potassium tert-butylate; In toluene; for 12h; Reflux;

Reference yield:

→ tert-butyl 4-(3-chlorophenyl)-4-cyanopiperidine-1-carboxylate (553631-33-7)

Guidance literature:

upstream raw materials:

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

3-chloro-benzeneacetonitrile

Downstream raw materials:

C₁₇H₂₅ClN₂O₂

4-(3-chlorophenyl)-piperidine-4-carbonitrile hydrochloride

4-cyano-4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

1-tert-butyl ethyl 4-(3-chlorophenyl)piperidine-1,4-dicarboxylate

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