Technology Process of 3-Pyridinol,5-ethyl-4-methyl-(9CI)
There total 4 articles about 3-Pyridinol,5-ethyl-4-methyl-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
t-butoxide;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1021/tx020095d
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent Chromat. / tetrahydrofuran / 4 h / 20 °C
2: 83.3 percent Chromat. / DMSO; oxalyl chloride; triethylamine / CH2Cl2 / 3.65 h / -78 - -60 °C
3: 73.0 percent Chromat. / t-butoxide / tetrahydrofuran / 24 h / 20 °C
With
oxalyl dichloride; t-butoxide; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
2: Swern oxidation;
DOI:10.1021/tx020095d
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 10 percent Pd/C / methanol; formic acid / 5 h / 20 °C
2: 90 percent Chromat. / tetrahydrofuran / 4 h / 20 °C
3: 83.3 percent Chromat. / DMSO; oxalyl chloride; triethylamine / CH2Cl2 / 3.65 h / -78 - -60 °C
4: 73.0 percent Chromat. / t-butoxide / tetrahydrofuran / 24 h / 20 °C
With
palladium on activated charcoal; oxalyl dichloride; t-butoxide; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; formic acid; dichloromethane;
3: Swern oxidation;
DOI:10.1021/tx020095d
