Technology Process of tert-Butyl 5-bromo-2-chlorobenzoate
There total 1 articles about tert-Butyl 5-bromo-2-chlorobenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-2-chlorobenzoic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
toluene;
at 20 ℃;
for 1.08333h;
potassium tert-butylate;
In
toluene;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisopropylamine; 1,3-bis-(diphenylphosphino)propane; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate / dimethyl sulfoxide / 20 h / 110 °C / Inert atmosphere
2: copper(ll) bromide / ethyl acetate; chloroform / 20 h / 80 °C / Inert atmosphere
With
1,3-bis-(diphenylphosphino)propane; palladium diacetate; diisopropylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; copper(ll) bromide;
In
chloroform; dimethyl sulfoxide; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diisopropylamine; 1,3-bis-(diphenylphosphino)propane; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate / dimethyl sulfoxide / 20 h / 110 °C / Inert atmosphere
2: copper(ll) bromide / ethyl acetate; chloroform / 20 h / 80 °C / Inert atmosphere
3: ethanol / 20 h / 20 °C
With
1,3-bis-(diphenylphosphino)propane; palladium diacetate; diisopropylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; copper(ll) bromide;
In
ethanol; chloroform; dimethyl sulfoxide; ethyl acetate;
