Cyclopentaneacetic acid, -alpha--acetyl-3-oxo-, methyl ester, (1R)- (9CI)

Base Information

• Chemical Name: Cyclopentaneacetic acid, -alpha--acetyl-3-oxo-, methyl ester, (1R)- (9CI)
• CAS No.: 568590-08-9
• Molecular Formula: C10H14O4
• Molecular Weight: 198.21576
• Mol file: 568590-08-9.mol

Synonyms:Cyclopentaneacetic acid, -alpha--acetyl-3-oxo-, methyl ester, (1R)- (9CI)

Chemical Property of Cyclopentaneacetic acid, -alpha--acetyl-3-oxo-, methyl ester, (1R)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Cyclopentaneacetic acid, -alpha--acetyl-3-oxo-, methyl ester, (1R)- (9CI)

There total 8 articles about Cyclopentaneacetic acid, -alpha--acetyl-3-oxo-, methyl ester, (1R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

cyclopent-2-enone (930-30-3) + acetoacetic acid methyl ester (105-45-3) → 3-[(acetyl)(methoxycarbonyl)methyl] cyclopentanone (568590-08-9,724774-84-9)

Guidance literature:

[(η6-C6Me6)Ir((S,S)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine)]; In tert-butyl alcohol; at 40 ℃; for 24h;

Reference yield: 75.0%

cyclopent-2-enone (930-30-3) + acetoacetic acid methyl ester (105-45-3) → 3-[(acetyl)(methoxycarbonyl)methyl]-1-cyclopentanone (646038-06-4,568590-08-9,724774-84-9)

Guidance literature:

With Ru[(R,R)-TsDPEN](C₆Me₆); In toluene; at 40 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol200649u

Reference yield:

cyclopent-2-enone (930-30-3) + acetoacetic acid methyl ester (105-45-3) → 3-[(acetyl)(methoxycarbonyl)methyl]-1-cyclopentanone (568590-08-9,724774-84-9) + 3-[(acetyl)(methoxycarbonyl)methyl]-1-cyclopentanone (646038-06-4,568590-08-9,724774-84-9)

Guidance literature:

With Ru[N-(p-PhSO₂)-(1R,2R)-diphenylethylenediamine]((CH₃)6C₆); In toluene; at 40 ℃; for 24h; Title compound not separated from byproducts;

DOI:10.1021/ja035435b

upstream raw materials:

cyclopent-2-enone

acetoacetic acid methyl ester

ethyl acetoacetate