1-Methyl-6,7-dihydro-1H-pyrrolo[3,2-C]pyridine

Base Information

• Chemical Name: 1-Methyl-6,7-dihydro-1H-pyrrolo[3,2-C]pyridine
• CAS No.: 569351-25-3
• Molecular Formula: C8H10N2
• Molecular Weight: 134.181
• DSSTox Substance ID: DTXSID30472034
• Wikidata: Q82300787
• Mol file: 569351-25-3.mol

Synonyms:1-METHYL-6,7-DIHYDRO-1H-PYRROLO[3,2-C]PYRIDINE;569351-25-3;1-methyl-6,7-dihydropyrrolo[3,2-c]pyridine;DTXSID30472034;AKOS006285764;AB44183;A898227

Chemical Property of 1-Methyl-6,7-dihydro-1H-pyrrolo[3,2-C]pyridine

Chemical Property:

• PSA: 17.29000
• LogP: 0.43570
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 134.084398327
• Heavy Atom Count: 10
• Complexity: 153

Purity/Quality:

98%min ^*data from raw suppliers

1-Methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C=CC2=C1CCN=C2

Technology Process of 1-Methyl-6,7-dihydro-1H-pyrrolo[3,2-C]pyridine

There total 5 articles about 1-Methyl-6,7-dihydro-1H-pyrrolo[3,2-C]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

N-(2-(1-methyl-1H-pyrrol-2-yl)ethyl)carboxamide (569351-24-2) → 1-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine (569351-25-3)

Guidance literature:

With trichlorophosphate; In toluene; for 3h; Heating;

DOI:10.1021/jm030080s

Reference yield: 22.6%

→ 1-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine (569351-25-3)

Guidance literature:

With trichlorophosphate; In ethyl acetate;

Reference yield:

N-methylpyrrole aldehyde (1192-58-1) → 1-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine (569351-25-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / NaOAc / 1.5 h / Heating

2: 69 percent / LiAlH₄ / tetrahydrofuran / 5 h / 20 °C

3: 60 percent / 7 h / Heating

4: 36 percent / POCl₃ / toluene / 3 h / Heating

With lithium aluminium tetrahydride; sodium acetate; trichlorophosphate; In tetrahydrofuran; toluene;

DOI:10.1021/jm030080s

upstream raw materials:

N-(2-(1-methyl-1H-pyrrol-2-yl)ethyl)carboxamide

N-methylpyrrole aldehyde

2-(2-Aminoethyl)-1-methylpyrrole

1-methyl-2-(E-2-nitroethenyl)-1H-pyrrole

Downstream raw materials:

1-methyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

Refernces

• 1、 Khorana, Nantaka,Smith, Carol,Herrick-Davis, Kathy,Purohit, Anil,Teitler, Milt,Grella, Brian,Dukat, Ma?gorzata,Glennon, Richard A.. "Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors". . p. 3930 - 3937. Retrieved 2007/10/03.