Piperidine, 1-[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]- (9CI)

Base Information

• Chemical Name: Piperidine, 1-[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]- (9CI)
• CAS No.: 570361-36-3
• Molecular Formula: C₁₄H₁₇N₃O
• Molecular Weight: 243.308
• Mol file: 570361-36-3.mol

Synonyms:Piperidine, 1-[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]- (9CI);1-[(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)CARBONYL]-PIPERIDINE

Chemical Property of Piperidine, 1-[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]- (9CI)

Chemical Property:

• PSA: 37.61000
• LogP: 2.20670

Purity/Quality:

1-[(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)CARBONYL]-PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidine, 1-[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]- (9CI)

There total 4 articles about Piperidine, 1-[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-aminopyridine (504-29-0) + 1-(piperidin-1-yl)-butane-1,3-dione (1128-87-6) → (2-methylimidazo[1,2-a]pyridin-3-yl)(piperidin-1-yl)methanone (570361-36-3)

Guidance literature:

With Bromotrichloromethane; potassium hydrogencarbonate; In acetonitrile; at 80 ℃;

DOI:10.1002/adsc.201501012

Reference yield: 92.0%

piperidine (110-89-4) + 2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride (135854-51-2) → (2-methylimidazo[1,2-a]pyridin-3-yl)(piperidin-1-yl)methanone (570361-36-3)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h;

DOI:10.3184/174751911X13026260434797

Reference yield:

methyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate (943112-78-5) → (2-methylimidazo[1,2-a]pyridin-3-yl)(piperidin-1-yl)methanone (570361-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sodium hydroxide / 3 h

2: thionyl chloride / 2 h / Reflux

3: triethylamine / dichloromethane / 0.5 h

With thionyl chloride; water; triethylamine; sodium hydroxide; In dichloromethane;

DOI:10.3184/174751911X13026260434797

upstream raw materials:

piperidine

2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride

methyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate

2-methylimidazo[1,2-a]pyridine-3-carboxylic acid