1128-87-6

Usage

Purification Methods

Dissolve it in *benzene, extract with 0.5M HCl to remove basic impurities, wash with water, dry, and distil it at 0.1mm [Wilson J Org Chem 28 314 1963]. [Beilstein 20 IV 1121.]

InChI:InChI=1/C9H15NO2/c1-8(11)7-9(12)10-5-3-2-4-6-10/h2-7H2,1H3

Upstream product

• 110-89-4 piperidine 
• 141-97-9 ethyl acetoacetate 
• 674-82-8 4-methyleneoxetan-2-one 
• 105-45-3 acetoacetic acid methyl ester 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 934370-33-9 2-Chloro-1-(piperidin-1-yl)butane-1,3-dione 
• 1694-31-1 tert-butyl acetoacetate 

Downstream Products

• 126274-26-8 3-[(4-Chloro-2-nitro-phenyl)-hydrazono]-1-piperidin-1-yl-butan-1-one 
• 83305-64-0 2-Benzyl-1-piperidin-1-yl-butane-1,3-dione 
• 135878-43-2 N-(2-((p-nitrobenzenesulfonyl)oxy)-1,3-dioxo-1-butyl)piperidine 
• 126274-20-2 3-[(2-Nitro-phenyl)-hydrazono]-1-piperidin-1-yl-butan-1-one 
• 83325-68-2 2-[(E)-Phenylimino]-1-piperidin-1-yl-butane-1,3-dione 
• 126274-27-9 3-[(2-Nitro-4-trifluoromethyl-phenyl)-hydrazono]-1-piperidin-1-yl-butan-1-one 
• 126274-25-7 3-[(4-Methyl-2-nitro-phenyl)-hydrazono]-1-piperidin-1-yl-butan-1-one 
• 1203506-45-9 (6-chloro-2-methyl-4-phenyl-3-quinolyl)(piperidino)methanone 
• 1415327-88-6 (4-(4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanone 
• 1415327-89-7 (6-methyl-2-thioxo-4-m-tolyl-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanone 
• 1415327-90-0 (4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanone 
• 1415327-91-1 (4-(4-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanone 
• 1415327-92-2 (4-(3-bromophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanone 
• 1415327-93-3 (4-(4-bromophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanone 

Relevant academic research and scientific papers

Tin(II) Amides: New Reagents for the Conversion of Esters to Amides

Mixed tin(II) amides are generated, in situ, via addition of aliphatic amines to Sn2.Condensation of these reagents with esters yields amides.

Intermolecular acetoxyaminoalkylation of α-diazo amides with (diacetoxyiodo)benzene and amines

Multicomponent reactions of diazo compounds have attracted much attention in recent years. Such transformations are generally conducted by applying transition metal catalysis and involve the corresponding metal carbenes as key intermediates. In this letter, a metal-free three-component intermolecular acetoxyaminoalkylation of α-diazo amides with tertiary aryl amines and (diacetoxyiodo)benzene is presented.

α-Crotyl-α-difluoroboranyloxy-amides: Structure and Reactivity of Isolable Intermediates in Stereospecific α-Ketol Rearrangements

The stereospecific BF3-mediated α-ketol rearrangement of β-hydroxy-α-ketoamides yields isolable 2-difluoroboranyloxy-3-keto-amides. X-ray and NMR analysis reveal a carbonyl coordination of the boron by the amide not the ketone. The boron complexes are air-stable solids, can be purified by silica gel chromatography, and exhibit novel reactivity in bromination and superior stereoselectivity in dipolar cycloaddition reactions.

Synthesis of α-Alkyl-β-Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases

Chiral (α-substituted) β-hydroxy amides are interesting derivatives as they are useful building blocks of many biologically active compounds. Herein, the biocatalytic stereocontrolled synthesis of various acyclic syn-α-alkyl-β-hydroxy amides through a dynamic kinetic resolution is shown. Hence, a series of overexpressed alcohol dehydrogenases (ADHs) in Escherichia coli was used to reduce the corresponding racemic β-keto amides. Among them, ADH-A from Rhodococcus ruber and commercial evo-1.1.200 afforded the best activities and selectivities, giving access to the opposite enantiomers with high diastereomeric excess and excellent enantiomeric excess. Some of these compounds were obtained at semipreparative scale. (Figure presented.).

Synthesis of β-Ketoamide Curcumin Analogs for Anti-Diabetic and AGEs Inhibitory Activities

Two different series of novel β-ketoamide curcumin analogs enriched in biological activities have been synthesized. The synthesized compounds were screened for their in?vitro anti-diabetic and AGEs inhibitory activities and exhibited potent to good anti-diabetic and AGEs inhibitory activities. The molecular docking study was also performed with the α-amylase enzyme.

COMPOSITIONS COMPRISING A POLYMERIC NETWORK

The present invention relates to a composition comprising a polymeric network having at least one unit of formula (I), (II), and/or (III); (I) (II) (III) wherein said composition is obtained by contacting at least one compound A comprising at least two functions selected from the group of function of formula X—C(═O)—CHR1—C(═O)—R2, —C(═O)—C—R2; or —C(═O)—CR1═CR2—NR4R5; wherein at least 25% by weight of compounds A have a functionality ≦5, with % by weight relative to the total weight of compounds A; with at least one compound B comprising at least one NH2, or NH3+ groups; wherein X, R1, R2, R3, R4, R5, L1 and L2 have the same meaning as that defined in the claims. The present invention also relates to a compound comprising at least two units and at most 5 units of formula (I), (II), and/or (III); wherein R1, R2, R3, X, L1 and L2 have the same meaning as that defined in the claims. The present invention also relates to processes for preparing said composition and said compounds, to material, articles, and polymers comprising or using said compositions and compounds, and the use thereof.

O -Iodoxybenzoic Acid (IBX)-Iodine Mediated One-Pot Deacylative Sulfonylation of 1,3-Dicarbonyl Compounds: A Synthesis of β-Carbonyl Sulfones

A combination of o-iodoxybenzoic acid (IBX) and a catalytic amount of iodine is found to promote a facile one-pot deacylative sulfonylation reaction of 1,3-dicarbonyl compounds with sodium sulfinates to yield β-carbonyl sulfones. The present method provides the target products bearing a wide variety of functional groups in one step and in good yields.

A convenient method for reduction dehalogenation of α-halocarbonyl compounds using benzenethiol in K+/CH3CN system

Benzenethiol, as a reductive agent for the dehalogenation of various α-halocarbonyl compounds, is investigated in the K+/CH3CN system. The reaction affords the reduced compounds in high yields under mild reaction conditions, especially α-chlorocarbonyl compounds. Furthermore, the reaction performed under ultrasonic irradiation greatly shortens the reaction time.

Regio- and diastereoselective crotylboration of vic-tricarbonyl compounds

Crotylboration of vic-diketoamides and vic-diketo esters was achieved with high diastereoselectivity and complementary regioselectivity. Whereas (E)-crotylboration of α,β-diketoamides resulted in high yields (91-99 %) of β-crotylated products obtained as a single diastereomer (anti), Lewis acid promoted crotylboration of α,β-diketo esters yielded the α-crotylated species with the anti product as main diastereomer. (E)-Crotylboration of α,β-diketoamides resulted in high yields (91-99 %) of β-crotylated products obtained as a single diastereomer (anti). Lewis acid promoted crotylboration of α,β-diketo esters yielded the α-crotylated species with the anti product as main diastereomer. Copyright

Fe(III) Complex Compounds For The Treatment And Prophylaxis Of Iron Deficiency Symptoms And Iron Deficiency Anemias

The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.