1H-Benzimidazole,2-(1H-pyrazol-1-yl)-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,2-(1H-pyrazol-1-yl)-(9CI)
• CAS No.: 6488-88-6
• Molecular Formula: C₁₀H₈N₄
• Molecular Weight: 184.2
• Hs Code.: 2933990090
• Mol file: 6488-88-6.mol

Synonyms:Benzimidazole,2-pyrazol-1-yl- (7CI,8CI); 2-(1-Pyrazolyl)benzimidazole;2-(1'-Pyrazolyl)benzimidazole

Chemical Property of 1H-Benzimidazole,2-(1H-pyrazol-1-yl)-(9CI)

Chemical Property:

• Melting Point: 220-221 °C
• Boiling Point: 427.7±28.0 °C(Predicted)
• PKA: 10.61±0.10(Predicted)
• PSA: 46.50000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: 1.74860

Purity/Quality:

98%min ^*data from raw suppliers

2-(1H-Pyrazol-1-yl)-1H-1,3-benzodiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,2-(1H-pyrazol-1-yl)-(9CI)

There total 8 articles about 1H-Benzimidazole,2-(1H-pyrazol-1-yl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(1H-benzimidazol-2-yl)-2-methyl-pyrazolium chloride (133797-82-7) → 2--benzimidazol (6488-88-6)

Guidance literature:

at 200 ℃; for 3h; under 0.1 - 0.4 Torr;

DOI:10.1021/jo00013a029

Reference yield: 98.0%

NH-pyrazole (288-13-1) + bis(trichloromethyl) carbonate (32315-10-9) + 1,2-diamino-benzene (95-54-5) → 2--benzimidazol (6488-88-6)

Guidance literature:

NH-pyrazole; 1,2-diamino-benzene; With trichlorophosphate; for 0.166667h;

bis(trichloromethyl) carbonate; at 110 ℃; for 16h;

DOI:10.1021/acs.inorgchem.1c02979

Reference yield: 90.0%

NH-pyrazole (288-13-1) + 1,3-dihydro-2H-benzimidazol-2-one (615-16-7) → 2--benzimidazol (6488-88-6)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 16h;

DOI:10.1021/jo201425q

upstream raw materials:

1-methyl-1H-pyrazole

2-chloro-1H-benzoimidazole

2-hydrazinobenzimidazole

malonaldehydebis(dimethylacetal)

Downstream raw materials:

1-methyl-2-(1-pyrazolyl)benzimidazole