sodium (6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-chlorophenyl)cyclopentanec arbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information

Chemical Name:sodium (6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-chlorophenyl)cyclopentanec arbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:143407-77-6
Molecular Formula:C₂₂H₂₂ClN₂O₆S*Na
Molecular Weight:500.935
Hs Code.:
Mol file:143407-77-6.mol

Synonyms:sodium (6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-chlorophenyl)cyclopentanec arbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Suppliers and Price of sodium (6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-chlorophenyl)cyclopentanec arbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of sodium (6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-chlorophenyl)cyclopentanec arbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Chemical Property:

Vapor Pressure:4.4E-25mmHg at 25°C
Boiling Point:772.1°Cat760mmHg
Flash Point:420.8°C
PSA：141.14000
Density:g/cm³
LogP:1.44760

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of sodium (6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-chlorophenyl)cyclopentanec arbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 4 articles about sodium (6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-chlorophenyl)cyclopentanec arbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

: 71501-44-5
1-(4-chlorophenyl)cyclopentane-1-carboxylic acid chloride

: 957-68-6
7-Aminocephalosporanic acid

: 143407-77-6
Sodium; (6R,7R)-3-acetoxymethyl-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; acetone; at 0 - 20 ℃; for 6h;
DOI:10.1007/BF00766460

Reference yield:

: 64399-26-4
1-(4-chlorophenyl)cyclopentanecarboxylic acid

: 143407-77-6
Sodium; (6R,7R)-3-acetoxymethyl-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 75.5 percent / KOH / various solvent(s) / 12 h / Heating

2: 60.1 percent / SOCl₂ / benzene / 8 h / Heating

3: 31.5 percent / NaHCO₃ / acetone; H₂O / 6 h / 0 - 20 °C

With potassium hydroxide; thionyl chloride; sodium hydrogencarbonate; In water; acetone; benzene;
DOI:10.1007/BF00766460

Reference yield:

: 80789-69-1
1-(4-chlorophenyl)cyclopentane-1-carboxylic acid

: 143407-77-6
Sodium; (6R,7R)-3-acetoxymethyl-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60.1 percent / SOCl₂ / benzene / 8 h / Heating

2: 31.5 percent / NaHCO₃ / acetone; H₂O / 6 h / 0 - 20 °C

With thionyl chloride; sodium hydrogencarbonate; In water; acetone; benzene;
DOI:10.1007/BF00766460