2,5-DICHLOROBENZYLAMINE

Base Information

• Chemical Name: 2,5-DICHLOROBENZYLAMINE
• CAS No.: 10224-70-1
• Molecular Formula: C7H7 Cl2 N
• Molecular Weight: 176.045
• Hs Code.: 2921420090
• Mol file: 10224-70-1.mol

Synonyms:Aniline,2,5-dichloro-N-methyl- (7CI,8CI); N-(2,5-Dichlorophenyl)methylamine

Chemical Property of 2,5-DICHLOROBENZYLAMINE

Chemical Property:

• Refractive Index: n20/D 1.579(lit.)
• Boiling Point: 74-76 °C0.1 mm Hg(lit.)
• PKA: 2.38±0.25(Predicted)
• Flash Point: >230 °F
• PSA: 12.03000
• Density: 1.3172 g/mL at 25 °C(lit.)
• LogP: 3.10810

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-DICHLORO-N-METHYLANILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DICHLOROBENZYLAMINE

There total 5 articles about 2,5-DICHLOROBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid-(2,5-dichloro-N-methyl-anilide) (21354-64-3) → 2,5-dichloro-N-methyl-aniline (10224-70-1)

Guidance literature:

acetic acid-(2,5-dichloro-N-methyl-anilide); With borane-THF; In tetrahydrofuran; at 20 ℃; for 2h;

With citric acid; In tetrahydrofuran; water;

Reference yield:

N-(2,5-dichlorophenyl)formamide (6639-55-0) → 2,5-dichloro-N-methyl-aniline (10224-70-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 20h; Yield given;

DOI:10.1021/jm970459c

Reference yield:

2,5 dichloroaniline (95-82-9) → 2,5-dichloro-N-methyl-aniline (10224-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 h / 100 - 105 °C

2: LiAlH₄ / tetrahydrofuran / 20 h / 25 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm970459c

upstream raw materials:

2,5 dichloroaniline

dimethyl sulfate

N-(2,5-dichlorophenyl)formamide

acetic acid-(2,5-dichloro-N-methyl-anilide)

Downstream raw materials:

C₈H₆Cl₃NO

2,5-dichloro-N-methyl-N-nitroso-aniline