N-(2,5-Dichlorophenyl)formamide

Base Information

• Chemical Name: N-(2,5-Dichlorophenyl)formamide
• CAS No.: 6639-55-0
• Molecular Formula: C7H5 Cl2 N O
• Molecular Weight: 190.029
• Hs Code.: 2924299090
• European Community (EC) Number: 229-645-8
• NSC Number: 49208
• UNII: JHP5GX8YER
• DSSTox Substance ID: DTXSID3064435
• Nikkaji Number: J298.028B
• Wikidata: Q81991541
• Mol file: 6639-55-0.mol

Synonyms:N-(2,5-Dichlorophenyl)formamide;6639-55-0;Formamide, N-(2,5-dichlorophenyl)-;2,5-Dichloro-1-formylaminobenzene;Formyl-2,5-dichloranilide;AI3-18914;EINECS 229-645-8;NSC 49208;NSC-49208;N-formyl-2,5-dichloroaniline;NSC49208;JHP5GX8YER;Formamide,5-dichlorophenyl)-;SCHEMBL1758631;DTXSID3064435;2,5-DICHLOROPHENYLFORMAMIDE;AKOS014313607

Chemical Property of N-(2,5-Dichlorophenyl)formamide

Chemical Property:

• Vapor Pressure: 3.65E-05mmHg at 25°C
• Boiling Point: 353.2°C at 760 mmHg
• Flash Point: 167.4°C
• PSA: 29.10000
• Density: 1.46g/cm³
• LogP: 3.27060
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 188.9748192
• Heavy Atom Count: 11
• Complexity: 142

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)NC=O)Cl

Technology Process of N-(2,5-Dichlorophenyl)formamide

There total 5 articles about N-(2,5-Dichlorophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formic acid (64-18-6) + 2,5 dichloroaniline (95-82-9) → N-(2,5-dichlorophenyl)formamide (6639-55-0)

Guidance literature:

at 20 ℃; for 4h; Green chemistry;

DOI:10.1016/j.crci.2013.02.020

Reference yield: 92.0%

2,5 dichloroaniline (95-82-9) + formic acid ethyl ester (109-94-4) → N-(2,5-dichlorophenyl)formamide (6639-55-0)

Guidance literature:

With immobilized H₂SO₄ on activated charcoal; at 54 ℃; for 0.5h;

Reference yield:

formic acid (64-18-6) + 2,3-dichloro-4-(2,5-dichloro-phenylimino)-crotonic acid → N-(2,5-dichlorophenyl)formamide (6639-55-0)

Guidance literature:

upstream raw materials:

formic acid

2,5 dichloroaniline

formic acid ethyl ester

formyl acetic anhydride

Downstream raw materials:

2,5-dichloro-N-methyl-aniline

C₃₀H₃₈Cl₂FN₃O₇

C₃₆H₄₃Cl₂N₃O₇

2-(5,5-spiroadamantyl-3-(3-(2-morpholinoethylamino)-3-oxopropyl)-1,2,4-trioxolan-3-yl)ethyl 2,5-dichlorophenylcarbamate