2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 10299-69-1
• Molecular Formula: C9H10N2
• Molecular Weight: 146.1891
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID10501553
• Wikidata: Q82354009
• Mol file: 10299-69-1.mol

Synonyms:2,3-Dimethyl-7-azaindole;10299-69-1;2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine;1H-PYRROLO[2,3-B]PYRIDINE, 2,3-DIMETHYL-;MFCD00513469;7-Aza-2,3-dimethyl-indol;SCHEMBL855363;2,3-Dimethyl-1,7-diazainden;DTXSID10501553;MXNHEZZBSKBOHW-UHFFFAOYSA-N;2 pound not3-Dimethyl-7-azaindole;AMY31822;AC1489;2,3 dimethylpyrrolo[2,3-b]pyridine;2,3-dimethylpyrrolo[2,3-b]pyridine;2,3-dimethylpyrrolo [2,3-b]pyridine;AKOS006272249;CS-11753;SY029402;FT-0688223;A896647

Chemical Property of 2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

• Melting Point: 136-138 °C
• Refractive Index: 1.644
• Boiling Point: 348.6±15.0 °C(Predicted)
• PKA: 8.07±0.40(Predicted)
• PSA: 28.68000
• Density: 1.145 g/cm³
• LogP: 2.17970
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 146.084398327
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(NC2=C1C=CC=N2)C

Technology Process of 2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

There total 13 articles about 2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

8-(2-methylprop-1-en-1-yl)tetrazolo[1,5-a]pyridine → 2,3-dimethyl-1H-pyrrolo[2,3-b]pyridine (10299-69-1)

Guidance literature:

With meso-tetraphenylporphyrin iron(III) chloride; zinc; In chlorobenzene; at 130 ℃; for 20h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.202014950

Reference yield: 43.0%

pyrid-2-ylhydrazine (4930-98-7) + butanone (78-93-3) → 2,3-dimethyl-1H-pyrrolo[2,3-b]pyridine (10299-69-1)

Guidance literature:

In acetic acid; for 2h; Heating;

DOI:10.3987/COM-06-S(K)22

Reference yield:

2-Hydroxy-2,3-dimethyl-2,3-dihydro-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester → 2,3-dimethyl-1H-pyrrolo[2,3-b]pyridine (10299-69-1)

Guidance literature:

With hydrogenchloride; at 50 ℃; for 0.666667h; Yield given;

DOI:10.1055/s-1996-4312

upstream raw materials:

pyrid-2-ylhydrazine

butanone

3-methylpyridin-2-ylamine

tert-butyl (3-methylpyridin-2-yl)carbamate

Downstream raw materials:

2,3-Dimethyl-7-(p-fluorophenacyl)pyrrolo[2,3.-b ]pyridine

2,3Dimethyl-7-(p-cyanophenacyl)pyrrolo[2,3-b]pyridine

2,3-Dimethyl-7-(p-bromophenacyl)pyrrolo[2,3-b]pyridine, hydrobromide

2,3-Dimethyl-7-(o-carboxyphenethyl)pyrrolo[2,3-b]pyridine