Ketone, 1-indanyl methyl, (R)-(-)- (8CI)

Base Information

• Chemical Name: Ketone, 1-indanyl methyl, (R)-(-)- (8CI)
• CAS No.: 10277-73-3
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.216
• Hs Code.: 2914399090
• Mol file: 10277-73-3.mol

Synonyms:Ketone, 1-indanyl methyl, (R)-(-)- (8CI)

Chemical Property of Ketone, 1-indanyl methyl, (R)-(-)- (8CI)

Chemical Property:

• PSA: 17.07000
• LogP: 2.30540

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ketone, 1-indanyl methyl, (R)-(-)- (8CI)

There total 3 articles about Ketone, 1-indanyl methyl, (R)-(-)- (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4-methyl-1,2-dihydronaphthalene (4373-13-1) → 1-(2,3-dihydro-1H-inden-1-yl)ethan-1-one (10277-73-3,68533-23-3,703-77-5) + 1-Methylnaphthalene (90-12-0,34475-76-8)

Guidance literature:

With PhI(OTs)OH; In acetonitrile; at 0 ℃; for 0.166667h;

DOI:10.1021/ol070027o

Reference yield:

4-methyl-1,2-dihydronaphthalene (4373-13-1) → 1-methyl-2-tetralone (4024-14-0) + 1-(2,3-dihydro-1H-inden-1-yl)ethan-1-one (10277-73-3,68533-23-3,703-77-5)

Guidance literature:

With thallium(III) nitrate trihydrate; In acetonitrile; at 0 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

DOI:10.1055/s-0028-1083308

Reference yield:

acetaldehyde (75-07-0,9002-91-9) → 1-indan-5-yl-ethanone (4228-10-8) + 1-(2,3-dihydro-1H-inden-4-yl)ethanone (38997-97-6) + 1-(2,3-dihydro-1H-inden-1-yl)ethan-1-one (10277-73-3,68533-23-3,703-77-5)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 1.25 h;

upstream raw materials:

acetaldehyde

4-methyl-1,2-dihydronaphthalene

Downstream raw materials:

2,3-dihydro-1H-inden-1-yl-acetate

1-acetylindan-1-ol