3-METHYL-5-PHENYLPYRIDINE

Base Information

• Chemical Name: 3-METHYL-5-PHENYLPYRIDINE
• CAS No.: 10477-94-8
• Molecular Formula: C12H11 N
• Molecular Weight: 169.226
• Hs Code.: 2933399990
• Mol file: 10477-94-8.mol

Synonyms:3-Picoline,5-phenyl- (6CI,7CI,8CI); 3-Methyl-5-phenylpyridine; 3-Phenyl-5-methylpyridine

Chemical Property of 3-METHYL-5-PHENYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.00345mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 160°C 14mm
• PKA: 5.14±0.20(Predicted)
• Flash Point: 123.1°C
• Density: 1,07 g/cm3
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methyl-5-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-5-PHENYLPYRIDINE

There total 16 articles about 3-METHYL-5-PHENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(Z)-4-methyl-2-phenylpent-2-enedinitrile → 3-methyl-5-phenylpyridine (10477-94-8)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2.5h;

DOI:10.1039/d0cc02938f

Reference yield: 88.0%

5-bromo-3-picoline (3430-16-8) + phenylboronic acid (98-80-6) → 3-methyl-5-phenylpyridine (10477-94-8)

Guidance literature:

With 1-butyl-3-methylimidazolium hexafluorophosphate; palladium diacetate; sodium carbonate; In water; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.3184/030823408X333481

Reference yield: 79.0%

N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine (1379538-73-4) → 3-methyl-5-phenylpyridine (10477-94-8)

Guidance literature:

N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Inert atmosphere;

With o-tetrachloroquinone; acetic acid; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ja303002a

upstream raw materials:

phenylacetaldehyde

propionaldehyde

3-Methyl-4-phenyl-pyridine-2,6-dicarboxylic acid

5-bromo-3-picoline

Downstream raw materials:

5-phenylnicotinic acid

4-formyl-1-[(5-phenyl-3-pyridinyl)methyl]-indole

Refernces

• 1、 Gao, Guo-Lin,Xia, Wujiong,Jain, Pankaj,Yu, Jin-Quan. "Pd(II)-Catalyzed C3-Selective Arylation of Pyridine with (Hetero)arenes". supporting information. p. 744 - 747. Retrieved 2016/03/01.
• 2、 Xie, Zheng,Wu, Pan,Cai, Liangzhen,Tong, Xiaofeng. "Palladium-catalyzed cyclization of vinyl iodide-tethered allensulfonamide". . p. 2160 - 2162. Retrieved 2014/04/03.