N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine

Base Information

• Chemical Name: N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine
• CAS No.: 1379538-73-4
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.359
• Mol file: 1379538-73-4.mol

Synonyms:N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine

Chemical Property of N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine

There total 1 articles about N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3--2-methylprop-1-ene (91230-06-7) + 1-Bromo-2-phenylacetylene (932-87-6) → N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine (1379538-73-4)

Guidance literature:

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In toluene; for 48h; Inert atmosphere; Reflux;

DOI:10.1021/ja303002a

Reference yield: 100.0%

N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine (1379538-73-4) → N-tert-butoxycarbonyl-3-methyl-5-phenyl-1,4-dihydropyridine (1379538-55-2)

Guidance literature:

N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ja303002a

Reference yield: 79.0%

N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine (1379538-73-4) → 3-methyl-5-phenylpyridine (10477-94-8)

Guidance literature:

N-(2-methylallyl)-N-tert-butoxycarbonyl-phenylethynylamine; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Inert atmosphere;

With o-tetrachloroquinone; acetic acid; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ja303002a

upstream raw materials:

3--2-methylprop-1-ene

1-Bromo-2-phenylacetylene

Downstream raw materials:

3-methyl-5-phenylpyridine

N-tert-butoxycarbonyl-3-methyl-5-phenyl-1,4-dihydropyridine