CAPRYLIC ACID N-SUCCINIMIDYL ESTER

Base Information

• Chemical Name: CAPRYLIC ACID N-SUCCINIMIDYL ESTER
• CAS No.: 14464-30-3
• Molecular Formula: C12H19 N O4
• Molecular Weight: 241.287
• Hs Code.: 2925190090
• Mol file: 14464-30-3.mol

Synonyms:2,5-Pyrrolidinedione,1-[(1-oxooctyl)oxy]- (9CI); Succinimide, N-(octanoyloxy)- (8CI);2,5-Dioxopyrrolidin-1-yl octanoate; Caprylic acid N-hydroxysuccinimide ester;N-(Octanoyloxy)succinimide; N-Hydroxysuccinimidyl caprylate

Chemical Property of CAPRYLIC ACID N-SUCCINIMIDYL ESTER

Chemical Property:

• Melting Point: 61-63 °C
• Boiling Point: 333.2±25.0 °C(Predicted)
• PSA: 63.68000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 1.89200
• Storage Temp.: −20°C

Purity/Quality:

97% ^*data from raw suppliers

(2,5-Dioxopyrrolidin-1-yl)Octanoate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2,5-Dioxopyrrolidin-1-yl) Octanoate is used in preparation of eliglustat and tartrate thereof.

Technology Process of CAPRYLIC ACID N-SUCCINIMIDYL ESTER

There total 9 articles about CAPRYLIC ACID N-SUCCINIMIDYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Octanoic acid (124-07-2) → 2,5-dioxopyrrolidin-1-yl octanoate (14464-30-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; for 6h;

DOI:10.1039/c5ra10209j

Reference yield: 92.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Octanal (124-13-0) → 2,5-dioxopyrrolidin-1-yl octanoate (14464-30-3)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 1h; Heating;

DOI:10.1002/adsc.200303195

Reference yield: 90.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Octanal (124-13-0) → 2,5-dioxopyrrolidin-1-yl octanoate (14464-30-3) + Octanoic acid (124-07-2)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; Heating;

DOI:10.1002/adsc.200303195

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Octanoic acid

di(succinimido) carbonate

octanol

Downstream raw materials:

benzyl 2,6-dideoxy-2,6-di(octanoylamino)-3-O--5-O-(tetrahydropyran-2-yl)-β-D-glucofuranoside

benzyl 2-(benzyloxycarbonylamino)-2,6-dideoxy-3-O--6-(octanoylamino)-5-O-(tetrahydropyran-2-yl)-β-D-glucofuranoside

benzyl 2,6-dideoxy-6-(eicosanoylamino)-3-O--2-(octanoylamino)-5-O-(tetrahydropyran-2-yl)-β-D-glucofuranoside

Capr-Ser(Bzl)-Asp(OBzl)-Ala-Arg(NO₂)-OMe

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