6-Fluoro-3-methylquinolin-4-ol

Base Information

• Chemical Name: 6-Fluoro-3-methylquinolin-4-ol
• CAS No.: 442-09-1
• Molecular Formula: C10H8 F N O
• Molecular Weight: 177.178
• Hs Code.: 2933499090
• European Community (EC) Number: 207-129-3
• DSSTox Substance ID: DTXSID70196065
• Nikkaji Number: J196.127F
• Wikidata: Q83069156
• Mol file: 442-09-1.mol

Synonyms:6-Fluoro-3-methylquinolin-4-ol;442-09-1;EINECS 207-129-3;C10H8FNO;SCHEMBL13991576;SCHEMBL18509297;6-Fluoro-3-methyl-4-quinolinol;DTXSID70196065

Chemical Property of 6-Fluoro-3-methylquinolin-4-ol

Chemical Property:

• Vapor Pressure: 0.00502mmHg at 25°C
• Boiling Point: 275.7°C at 760 mmHg
• Flash Point: 120.5°C
• PSA: 32.86000
• Density: 1.228g/cm³
• LogP: 1.97560
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 177.058992041
• Heavy Atom Count: 13
• Complexity: 262

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CNC2=C(C1=O)C=C(C=C2)F

Technology Process of 6-Fluoro-3-methylquinolin-4-ol

There total 3 articles about 6-Fluoro-3-methylquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-fluoro-4-hydroxy-3-methyl-quinoline-2-carboxylic acid (318-33-2) → 6-fluoro-3-methyl-quinolin-4-ol (442-09-1)

Guidance literature:

With paraffin oil; at 270 - 280 ℃;

DOI:10.1021/ja01183a037

Reference yield:

6-fluoro-4-hydroxy-3-methyl-quinoline-2-carboxylic acid ethyl ester (343-09-9) → 6-fluoro-3-methyl-quinolin-4-ol (442-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaOH

2: paraffin oil / 270 - 280 °C

With sodium hydroxide; paraffin oil;

DOI:10.1021/ja01183a037

Reference yield:

4-fluoroaniline (371-40-4) → 6-fluoro-3-methyl-quinolin-4-ol (442-09-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Erhitzen des Reaktionsprodukts in Mineraloel auf 255grad

2: aqueous NaOH

3: paraffin oil / 270 - 280 °C

With sodium hydroxide; paraffin oil;

DOI:10.1021/ja01183a037

upstream raw materials:

6-fluoro-4-hydroxy-3-methyl-quinoline-2-carboxylic acid

6-fluoro-4-hydroxy-3-methyl-quinoline-2-carboxylic acid ethyl ester

4-fluoroaniline