3,5-DI-Tert-butyl-4-hydroxy-benzyl-hydrazine

Base Information

• Chemical Name: 3,5-DI-Tert-butyl-4-hydroxy-benzyl-hydrazine
• CAS No.: 6392-47-8
• Molecular Formula: C15H26 N2 O
• Molecular Weight: 250.384
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID20534756
• Nikkaji Number: J3.575.606J
• Wikidata: Q82408726
• Mol file: 6392-47-8.mol

Synonyms:6392-47-8;3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYL-HYDRAZINE;2,6-Di-tert-butyl-4-(hydrazinylmethyl)phenol;SCHEMBL11775795;DTXSID20534756

Chemical Property of 3,5-DI-Tert-butyl-4-hydroxy-benzyl-hydrazine

Chemical Property:

• PSA: 58.28000
• LogP: 4.04170
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 250.204513457
• Heavy Atom Count: 18
• Complexity: 241

Purity/Quality:

3,5-Di-tert-butyl-4-hydroxy-benzyl-hydrazine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CNN

Technology Process of 3,5-DI-Tert-butyl-4-hydroxy-benzyl-hydrazine

There total 4 articles about 3,5-DI-Tert-butyl-4-hydroxy-benzyl-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-((3,5-di-tert-butyl-4-hydroxybenzyl)thio) nicotinate → 2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid hydrazide + 3,5-di(t-butyl)-4-hydroxyphenyl hydrazine (6392-47-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 30 ℃; Solvent; Kinetics;

DOI:10.1016/j.tet.2015.10.077

Reference yield:

3,5-di-tert-butyl-4-hydroxybenzyl alcohol (88-26-6) → 3,5-di(t-butyl)-4-hydroxyphenyl hydrazine (6392-47-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / 7 h / Reflux

2: toluene-4-sulfonic acid / 6 h / Reflux

3: hydrazine hydrate / ethanol / 30 °C

With toluene-4-sulfonic acid; hydrazine hydrate; In ethanol; toluene;

DOI:10.1016/j.tet.2015.10.077

Reference yield:

2-((3,5-di-tert-butyl-4-hydroxybenzyl)thio) nicotinic acid → 2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid hydrazide + 3,5-di(t-butyl)-4-hydroxyphenyl hydrazine (6392-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 6 h / Reflux

2: hydrazine hydrate / ethanol / 30 °C

With toluene-4-sulfonic acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.tet.2015.10.077

upstream raw materials:

3,5-di-tert-butyl-4-hydroxybenzyl alcohol

Downstream raw materials:

bis(pentafluoroethyl)phosphinyl N-[3,5-di(t-butyl)-4-hydroxybenzyl]hydrazide

N,N'-bis-diethoxythiophosphoryl-N-(3,5-ditert-butyl-4-hydroxybenzyl)-hydrazine