4-Pyridinecarboxylicacid,2-phenyl-,hydrazide(9CI)

Base Information

• Chemical Name: 4-Pyridinecarboxylicacid,2-phenyl-,hydrazide(9CI)
• CAS No.: 58481-06-4
• Molecular Formula: C12H11N3O
• Molecular Weight: 213.2352
• Mol file: 58481-06-4.mol

Synonyms:2-Phenylisonicotinicacid hydrazide;

Chemical Property of 4-Pyridinecarboxylicacid,2-phenyl-,hydrazide(9CI)

Chemical Property:

• Refractive Index: 1.617
• PSA: 68.01000
• Density: 1.215 g/cm³
• LogP: 2.44330

Purity/Quality:

99% ^*data from raw suppliers

2-PHENYL-4-PYRIDINECARBOXYLIC ACID HYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarboxylicacid,2-phenyl-,hydrazide(9CI)

There total 4 articles about 4-Pyridinecarboxylicacid,2-phenyl-,hydrazide(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenylpyridine-4-carboxylic acid (55240-51-2) → 2-phenylisonicotinohydrazide (58481-06-4)

Guidance literature:

2-phenylpyridine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrazine; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2009.08.091

Reference yield:

ethyl 2-phenylpyridine-4-carboxylate (92199-59-2) → 2-phenylisonicotinohydrazide (58481-06-4)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1002/hlca.19550380425

Reference yield:

2-chloro-6-phenylisonicotinoyl chloride (1045325-76-5) → 2-phenylisonicotinohydrazide (58481-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol

2: palladium/charcoal; ethanol; potassium acetate / Hydrogenation

3: ethanol; N₂H₄+H₂O

With palladium on activated charcoal; ethanol; potassium acetate; hydrazine hydrate;

DOI:10.1002/hlca.19550380425

upstream raw materials:

ethyl 2-phenylpyridine-4-carboxylate

2-chloro-6-phenylisonicotinoyl chloride

2-chloro-6-phenyl-isonicotinic acid ethyl ester

2-phenylpyridine-4-carboxylic acid

Downstream raw materials:

potassium 2-(2-phenylisonicotinoyl)hydrazinecarbodithioate

5-(1-oxy-pyridin-4-yl)-3-(2-phenyl-pyridin-4-yl)-1,2,4-triazole