92199-59-2

Upstream product

• 92290-75-0 2-chloro-6-phenyl-isonicotinic acid ethyl ester 
• 126814-04-8 2-(1-phenyl-5-tetrazolyloxy)-4-carboethoxy-6-phenylpyridine 
• 1045325-76-5 2-chloro-6-phenylisonicotinoyl chloride 
• 54453-93-9 ethyl 2-chloroisonicotinate 
• 98-80-6 phenylboronic acid 
• 3144-09-0 methanesulfonamide 
• 66680-87-3 (E)-1-phenyl-(2-tributylstannyl)ethene 
• 949101-64-8 C₁₅H₁₇NO₄S 
• 1570-45-2 isonicotinic acid ethylester 
• 64-17-5 ethanol 
• 89937-77-9 methyl 2-oxo-1,2-dihydropyridine-4-carboxylate 
• 126814-01-5 6-phenyl-4-carboethoxy-2-pyridone 

Downstream Products

• 91973-38-5 2-phenylisonicotinamide 
• 58481-06-4 2-phenylisonicotinohydrazide 
• 4634-12-2 4-(hydroxymethyl)-2-phenylpyridine 
• 147937-35-7 4-chloromethyl-2-phenylpyridine 
• 33744-17-1 2-phenylpyridine-4-carbonitrile 
• 96982-28-4 2-phenyl-thioisonicotinic acid amide 

Relevant academic research and scientific papers

A novel strategy for the synthesis of 2-arylpyridines using one-pot 6π-azaelectrocyclization

A novel and useful method for the synthesis of 2-arylpyridines with a high efficiency and generality was achieved by utilizing the one-pot 6π-azaelectrocyclization followed by a base treatment. This is the first example of applying a sulfonamide to the azaelectrocyclization for efficient substituted pyridine synthesis.

Iridium (III) complex, preparation method and application thereof

The invention provides an iridium (III) complex. A 2-phenylethyl isonicotinate derivative is used as the main ligand, and 3,6-di-tert-butyl -9-(4-(4,5)-dimethyl-2-(pyrid-2-yl)-1H-imidazol-1-yl) butyl)-9H-carbazole is used as the auxiliary ligand. The irid

Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates

A selection of heteroaryl fluorosulfates were readily synthesized using commercial SO2F2 gas. These substrates are highly efficient coupling partners in the Suzuki reaction. Through judicious selection of Pd catalysts the fluorosulfate functionality is differentiated from bromide and chloride; the order of reactivity being: -Br> -OSO2F> -Cl. Exploiting this trend allowed the stepwise chemoselective synthesis of a number of polysubstituted pyridines, including the drug Etoricoxib. A selection of heteroaryl fluorosulfates were readily synthesized using commercial SO2F2 gas. These substrates are highly efficient coupling partners in the Suzuki reaction. Through judicious selection of Pd catalysts the fluorosulfate functionality is differentiated from bromide and chloride; the order of reactivity being: -Br> -OSO2F> -Cl. Exploiting this trend allowed the stepwise chemoselective synthesis of a number of polysubstituted pyridines, including the drug Etoricoxib.

Pyridine derivatives directly aromatise process (by machine translation)

The invention relates to the technical field of preparation processes of aromatic pyridine derivatives, and in particular relates to a direct aromatization process of a pyridine derivative. The process comprises the following flows of adding the pyridine derivative, arylboronic acid, ferrite and trifluoroacetic acid to a flask in sequence, stirring the mixture uniformly at room temperature, adding persulfate, continuing stirring, and filtering, extracting, concentrating and separating the obtained product after reaction is completed, thus obtaining the aromatized pyridine derivative. The direct aromatization process has the beneficial effects that ferrite is adopted as a catalyst, persulfate is adopted as an oxidant, arylboronic acid is promoted to generate aryl free radicals in the persulfate radical and ferrous oxide ion reaction process, and the aryl free radicals are added to the pyridine derivative, thus obtaining the corresponding product; the direct aromatization process is relatively low in production cost and relatively high in reaction yield, and is suitable for popularization and use.

Direct arylation of substituted pyridines with arylboronic acids catalyzed by iron(II) oxalate

The direct arylation of substituted pyridines with several arylboronic acids has been developed. This transformation could proceed readily at ambient temperature using inexpensive reagents: iron(II) oxalate as a catalyst, potassium persulfate as a co-oxidant, which can afford the arylated products in mild to good yields. The mechanism is presumed to proceed through a nucleophilic radical addition to the pyridines with in situ reoxidation.

Iron-mediated direct arylation with arylboronic acids through an aryl radical transfer pathway

A novel iron-mediated direct C-H arylation of quinones and pyridine analogues with arylboronic acids has been developed using dichloromethane and water as solvents at ambient temperature. FeS is employed and serves as an efficient catalyst. A detailed reaction mechanism is speculated and expounded.

Library-directed solution-And solid-phase synthesis of 2,4-disubstituted pyridines: one-pot approach through 6π-azaelectrocyclization

An efficient one-pot synthetic procedure for the synthesis of 2,4-disubstituted pyridines has been successfully established. The method proceeds through a 6π-azaelectrocyclization-aromatization sequence. Using this method, a wide variety of pyridine struc

Unsymmetrical cyclic diamine compound

A cyclic diamine compound of formula (1): wherein A is (CH2)n, (CH2)n—CH═CH, CO—(CH2)n or CO—(CH2)n—CH═CH, in which n is a number of 0 to 3; Z represents a formula (2) or (3): in which R1, R2, R4, R5 and R6 are individually a hydrogen atom, alkyl group, alkoxy group, halogen atom or nitro group; R3 is a hydrogen atom, alkyl group, alkoxy group, halogen atom, nitro group, naphthyl group, or phenyl group which may be substituted by 1 to 3 substituents selected from the group consisting of alkyl groups, alkoxy groups, halogen atoms, a nitro group and a phenyl group; and X and Y are individually CH or a nitrogen atom; and m is 1 or 2; an acid-addition salt thereof, or a hydrate thereof, and a medicine containing such a compound.

DEOXYGENATION OF PYRIDONES VIA THEIR TETRAZOLYL ETHERS

A mild process for the conversion of pyridones to the corresponding pyridines by palladium catalyzed ammonium formate hydrogenolysis of their (1-phenyltetrazol-2-yl)ethers is described.