2-Oxiranylmethyl trifluoroacetate

Base Information

• Chemical Name: 2-Oxiranylmethyl trifluoroacetate
• CAS No.: 69161-63-3
• Molecular Formula: C5H5F3O3
• Molecular Weight: 0
• Mol file: 69161-63-3.mol

Synonyms:2-Oxiranylmethyl trifluoroacetate

Chemical Property of 2-Oxiranylmethyl trifluoroacetate

Chemical Property:

• PSA: 38.83000
• LogP: 0.49070

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Oxiranylmethyl trifluoroacetate

There total 3 articles about 2-Oxiranylmethyl trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

oxiranyl-methanol (556-52-5) + trifluoroacetic anhydride (407-25-0) → (RS)-<<(trifluoromethanesulfonyl)oxy>methyl>oxirane (69161-63-3)

Guidance literature:

With pyridine; In dichloromethane; for 0.75h;

DOI:10.1021/jm00350a009

Reference yield:

trifluoroacetic anhydride (407-25-0) + (R)-oxiranemethanol (57044-25-4) → (S)-<<(trifluoromethanesulfonyl)oxy>methyl>oxirane (69161-63-3)

Guidance literature:

With pyridine; In dichloromethane; for 0.75h; Yield given;

DOI:10.1021/jm00350a009

Reference yield:

→ (RS)-<<(trifluoromethanesulfonyl)oxy>methyl>oxirane (69161-63-3)

Guidance literature:

(CF3CO)2O, Glycidol-Pyridin;

DOI:10.1016/0009-3084(78)90020-8

upstream raw materials:

oxiranyl-methanol

trifluoroacetic anhydride

(R)-oxiranemethanol

Refernces

• 1、 Baldwin,McClure,Gross,Williams. "Use of (S)-(Trifloxymethyl)oxirane in the synthesis of a chiral β-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene". . p. 931 - 936. Retrieved 2007/10/02.