5-Bromoimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 5-Bromoimidazo[1,2-a]pyridine
• CAS No.: 69214-09-1
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933599590
• European Community (EC) Number: 640-633-5
• DSSTox Substance ID: DTXSID10515998
• Nikkaji Number: J3.519.579C
• Wikidata: Q72457110
• Mol file: 69214-09-1.mol

Synonyms:5-bromoimidazo(1,2-a)pyridine

Chemical Property of 5-Bromoimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 61-64℃
• Refractive Index: 1.688
• PKA: 5.15±0.50(Predicted)
• PSA: 17.30000
• Density: 1.697 g/cm³
• LogP: 2.09680
• Storage Temp.: Room temperature.
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 195.96361
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromoimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN2C(=C1)Br
• Uses: 5-Bromoimidazo[1,2-a]pyridine can be used as HPK1 antagonists to treat HPK1-mediated disorders.

Technology Process of 5-Bromoimidazo[1,2-a]pyridine

There total 4 articles about 5-Bromoimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromoimidazo[1,2-a]pyridine hydrobromide (603301-13-9) → 5-bromoimidazo<1,2-a>pyridine (69214-09-1)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate;

Reference yield: 79.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + bromoacetaldehyde (17157-48-1) → 5-bromoimidazo<1,2-a>pyridine (69214-09-1)

Guidance literature:

In ethanol; for 6h; Heating;

Reference yield: 74.0%

2-chloroethanal (107-20-0) + 2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) → 5-bromoimidazo<1,2-a>pyridine (69214-09-1)

Guidance literature:

In ethyl [2]alcohol; for 20h; Reflux;

DOI:10.1039/c5cc08716c

upstream raw materials:

2-Amino-6-bromopyridine

bromoacetaldehyde

5-bromoimidazo[1,2-a]pyridine hydrobromide

5-bromo-2-pyridylamine

Downstream raw materials:

5-bromo-3-nitroimidazo<1,2-a>pyridine

3,5-dibromoimidazo<1,2-a>pyridine

3-acetyl-5-bromoimidazo[1,2-a]pyridine

2-Amino-6-bromopyridine

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