Acetic acid acetoxy-(4-chlorosulfonylphenyl)methyl ester

Base Information

• Chemical Name: Acetic acid acetoxy-(4-chlorosulfonylphenyl)methyl ester
• CAS No.: 69232-47-9
• Molecular Formula: C11H11ClO6S
• Molecular Weight: 306.724
• Hs Code.: 2916399090
• Mol file: 69232-47-9.mol

Synonyms:Benzenesulfonyl chloride, 4-[bis(acetyloxy)methyl]-;

Chemical Property of Acetic acid acetoxy-(4-chlorosulfonylphenyl)methyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 111-113 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
• Refractive Index: 1.535
• Boiling Point: 406.457 °C at 760 mmHg
• Flash Point: 199.618 °C
• PSA: 95.12000
• Density: 1.419 g/cm³
• LogP: 2.81970
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(4-(Chlorosulfonyl)phenyl)methylenediacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid acetoxy-(4-chlorosulfonylphenyl)methyl ester

There total 4 articles about Acetic acid acetoxy-(4-chlorosulfonylphenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.7%

acetic anhydride (108-24-7) + acetic acid (64-19-7,77671-22-8) + p-toluenesulfonyl chloride (98-59-9) → (4-(chlorosulfonyl)phenyl)methylene diacetate (69232-47-9)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; at 0 ℃; for 0.583333h; Product distribution / selectivity;

Reference yield: 38.0%

acetic anhydride (108-24-7) + p-toluenesulfonyl chloride (98-59-9) → (4-(chlorosulfonyl)phenyl)methylene diacetate (69232-47-9)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; acetic acid; cooling;

DOI:10.1016/j.bmc.2006.02.013

Reference yield: 33.0%

p-toluenesulfonyl chloride (98-59-9) + dimethyl dicarbonate (4525-33-1) → (4-(chlorosulfonyl)phenyl)methylene diacetate (69232-47-9)

Guidance literature:

With sulfuric acid; chromium(VI) oxide; In acetic acid; at 0 - 10 ℃; for 0.5h;

upstream raw materials:

acetic anhydride

p-toluenesulfonyl chloride

dimethyl dicarbonate

acetic acid

Downstream raw materials:

N-(4-diacetoxymethyl-benzenesulfonyl)-N'-isonicotinoyl-hydrazine

4-[bis(acetyloxy)methyl]benzenesulfonamide

benzaldehyde-4-sulfonic acid

C₁₆H₂₁NO₆S

Refernces

• 1、 -. "CRTH2 MODULATORS". Page/Page column 92. . Retrieved 2010/04/27.
• 2、 -. "INDOLIZINE ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS". Page/Page column 11. . Retrieved 2008/12/07.