1-(4-Phenyl-1,3-thiazol-2-yl)piperazine

Base Information

Chemical Name:1-(4-Phenyl-1,3-thiazol-2-yl)piperazine
CAS No.:69389-14-6
Molecular Formula:C13H15 N3 S
Molecular Weight:245.348
Hs Code.:
DSSTox Substance ID:DTXSID30351890
Wikidata:Q82128704
Mol file:69389-14-6.mol

Synonyms:69389-14-6;1-(4-phenyl-1,3-thiazol-2-yl)piperazine;4-phenyl-2-piperazin-1-yl-1,3-thiazole;1-(4-Phenyl-2-thiazolyl)-piperazine;4-Phenyl-2-(piperazin-1-yl)thiazole;4-Phenyl-2-piperazino-1,3-thiazole;1-(4-Phenyl-2-thiazolyl)piperazine;Piperazine, 1-(4-phenyl-2-thiazolyl)-;ChemDiv2_002645;SCHEMBL2710025;DTXSID30351890;HMS1376I05;MFCD03197046;STK132338;AKOS003292362;Piperazine, 1-(4-phenylthiazol-2-yl)-;FT-0761388;Z57479714

Suppliers and Price of 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Phenyl-1,3-thiazol-2-yl)piperazine
100mg
$ 470.00

Crysdot
4-Phenyl-2-(piperazin-1-yl)thiazole 97%
1g
$ 441.00

Crysdot
4-Phenyl-2-(piperazin-1-yl)thiazole 97%
10g
$ 1295.00

Crysdot
4-Phenyl-2-(piperazin-1-yl)thiazole 97%
5g
$ 917.00

American Custom Chemicals Corporation
1-(4-PHENYL-2-THIAZOLYL)-PIPERAZINE 95.00%
5MG
$ 498.77

Total 4 raw suppliers

Chemical Property of 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine

Chemical Property:

Vapor Pressure:2.21E-07mmHg at 25°C
Refractive Index:1.605
Boiling Point:423.6°C at 760 mmHg
Flash Point:210°C
PSA：56.40000
Density:1.192g/cm³
LogP:2.61350
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:245.09866866
Heavy Atom Count:17
Complexity:237

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Phenyl-1,3-thiazol-2-yl)piperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=NC(=CS2)C3=CC=CC=C3
Uses 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine is used as an antidiabetic agent.

Technology Process of 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine

There total 7 articles about 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 887624-04-6
tert-butyl 4-(4-phenylthiazol-2-yl)piperazine-1-carboxylate

: 69389-14-6
4-phenyl-2-(piperazin-1-yl)thiazole

Guidance literature:: With hydrogenchloride; water; In ethyl acetate; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2012.11.006

Reference yield:

: 70-11-1
α-bromoacetophenone

: 69389-14-6
4-phenyl-2-(piperazin-1-yl)thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 3 h / 80 °C

2: hydrogen bromide / acetic acid / 3 h / 130 °C

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C

4: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; water; hydrogen bromide; potassium carbonate; In ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.006

Reference yield:

: 5399-30-4
2-oxo-2-phenylethylthiocyanate

: 69389-14-6
4-phenyl-2-(piperazin-1-yl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / acetic acid / 3 h / 130 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C

3: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; water; hydrogen bromide; potassium carbonate; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.006