3-(3-PYRIDYL)-2-PROPEN-1-OL

Base Information

• Chemical Name: 3-(3-PYRIDYL)-2-PROPEN-1-OL
• CAS No.: 69963-46-8
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2933399090
• Mol file: 69963-46-8.mol

Synonyms:3-(3-Pyridinyl)-2-propen-1-ol;3-(3-Pyridyl)allyl Alcohol

Chemical Property of 3-(3-PYRIDYL)-2-PROPEN-1-OL

Chemical Property:

• Boiling Point: 284.5±20.0 °C(Predicted)
• PKA: 14.20±0.10(Predicted)
• PSA: 33.12000
• Density: 1.115±0.06 g/cm3(Predicted)
• LogP: 1.08710
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(3-Pyridyl)-2-propen-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A antihypertensives and platelet aggregation inhibitors.

Technology Process of 3-(3-PYRIDYL)-2-PROPEN-1-OL

There total 6 articles about 3-(3-PYRIDYL)-2-PROPEN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-pyridylboronic acid (1692-25-7) + allyl alcohol (107-18-6) → 3-(3-pyridinyl)propionaldehyde (1802-16-0) + 3-(pyridin-3-yl)prop-2-en-1-ol (69963-46-8)

Guidance literature:

With [2,2]bipyridinyl; palladium diacetate; at 80 ℃; for 12h; Green chemistry;

DOI:10.1016/j.tetlet.2018.02.021

Reference yield:

3-(pyridin-3-yl)acrylic acid ethyl ester (28447-17-8) → 3-(pyridin-3-yl)prop-2-en-1-ol (69963-46-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran;

DOI:10.1002/anie.201704354

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) → 3-(pyridin-3-yl)prop-2-en-1-ol (69963-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Na / ethanol / 2 h / -15 - -5 °C

2: diisobutylaluminiumhydride / toluene / 15 h / Ambient temperature

With sodium; diisobutylaluminium hydride; In ethanol; toluene;

DOI:10.1021/jo00005a046

upstream raw materials:

ethyl (E)-3-(pyridin-3-yl)acrylate

3-pyridinecarboxaldehyde

3-(pyridin-3-yl)acrylic acid ethyl ester

3-pyridylboronic acid

Downstream raw materials:

3-(3-pyridyl)acrolein