(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-1-methylpiperidine

Base Information

Chemical Name:(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-1-methylpiperidine
CAS No.:600135-83-9
Molecular Formula:C27H30FNO3
Molecular Weight:435.539
Hs Code.:
Mol file:600135-83-9.mol

Synonyms:(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-1-methylpiperidine

Suppliers and Price of (3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-1-methylpiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(benzyloxy)phenoxy]methyl]-1-methylpiperidine
100mg
$ 1230.00

American Custom Chemicals Corporation
(3S,4R)-4-(4-FLUOROPHENYL)-3-[[3-METHOXY-4-(PHENYLMETHOXY)PHENOXY]METHYL]-1-METHYLPIPERIDINE 95.00%
100MG
$ 1871.10

American Custom Chemicals Corporation
(3S,4R)-4-(4-FLUOROPHENYL)-3-[[3-METHOXY-4-(PHENYLMETHOXY)PHENOXY]METHYL]-1-METHYLPIPERIDINE 95.00%
10MG
$ 739.20

American Custom Chemicals Corporation
(3S,4R)-4-(4-FLUOROPHENYL)-3-[[3-METHOXY-4-(BENZYLOXY)PHENOXY]METHYL]-1-METHYLPIPERIDINE 95.00%
5MG
$ 504.86

Total 2 raw suppliers

Chemical Property of (3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-1-methylpiperidine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.562
Boiling Point:549.925°C at 760 mmHg
Flash Point:286.384°C
PSA：30.93000
Density:1.134g/cm³
LogP:5.46550
Solubility.:Chloroform, Methanol

Purity/Quality:

97% ^*data from raw suppliers

(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(benzyloxy)phenoxy]methyl]-1-methylpiperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-1-methylpiperidine

There total 2 articles about (3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-1-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 40232-88-0
4-benzyloxy-3-methoxyphenol

: 317323-77-6
((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methyl 4-methylbenzenesulfonate

: 600135-83-9
(3S,4R)-4-(4-fluorophenyl)-3-(3-methoxy-4-benzyloxyphenoxymethyl)-1-methylpiperidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 4h; Heating;
DOI:10.1016/S0045-2068(03)00040-3

Reference yield:

: 105812-81-5
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

: 600135-83-9
(3S,4R)-4-(4-fluorophenyl)-3-(3-methoxy-4-benzyloxyphenoxymethyl)-1-methylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / trimethylamine hydrochloride / CH₂Cl₂ / 4 h / cooling

2: 53 percent / NaH / dimethylformamide / 4 h / Heating

With trimethylamine hydrochloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0045-2068(03)00040-3