4-(2-METHOXYETHOXY)-4-OXOBUTANOIC ACID

Base Information

• Chemical Name: 4-(2-METHOXYETHOXY)-4-OXOBUTANOIC ACID
• CAS No.: 6946-89-0
• Molecular Formula: C7H12 O5
• Molecular Weight: 176.1672
• Mol file: 6946-89-0.mol

Synonyms:Butanedioicacid, mono(2-methoxyethyl) ester (9CI); Succinic acid, mono(2-methoxyethyl)ester (8CI); NSC 57376

Chemical Property of 4-(2-METHOXYETHOXY)-4-OXOBUTANOIC ACID

Chemical Property:

• Vapor Pressure: 0.000103mmHg at 25°C
• Boiling Point: 314.1°C at 760 mmHg
• Flash Point: 127.2°C
• PSA: 72.83000
• Density: 1.185g/cm³
• LogP: 0.04080

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Methoxyethoxy)-4-oxobutanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-METHOXYETHOXY)-4-OXOBUTANOIC ACID

There total 1 articles about 4-(2-METHOXYETHOXY)-4-OXOBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

succinic acid anhydride (108-30-5) + 2-methoxy-ethanol (109-86-4,95507-80-5) → 4-(2-methoxyethoxy)-4-oxobutanoic acid (6946-89-0)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c4tb00134f

Reference yield: 42.0%

4-(2-methoxyethoxy)-4-oxobutanoic acid (6946-89-0) + 2-(3-pentadecy-8-en-1-yl)phenoxyethanamine → 2-methoxyethyl 4-oxo-4-((2-(3-pentadecylphenoxy)ethyl)amino)butanoate (1616867-97-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c4tb00134f

upstream raw materials:

succinic acid anhydride

2-methoxy-ethanol

Downstream raw materials:

2-methoxyethyl 4-oxo-4-((2-(3-pentadecylphenoxy)ethyl)amino)butanoate

Refernces

• 1、 -. "BIOPSY METHODS AND DEVICES". Paragraph 0137; 0138; 0139. . Retrieved 2018/12/02.