Furo[3,2-C]pyridine-7-methanol

Base Information

• Chemical Name: Furo[3,2-C]pyridine-7-methanol
• CAS No.: 603302-91-6
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.14668
• DSSTox Substance ID: DTXSID50591958
• Wikidata: Q82485831
• Mol file: 603302-91-6.mol

Synonyms:FURO[3,2-C]PYRIDINE-7-METHANOL;603302-91-6;(Furo[3,2-c]pyridin-7-yl)methanol;Furo[3,2-c]pyridin-7-ylmethanol;SCHEMBL2261557;DTXSID50591958;QDBRSUCMTUHRPH-UHFFFAOYSA-N;Furo[3,2-c]pyridine-7-methanol(9ci);DB-265138

Chemical Property of Furo[3,2-C]pyridine-7-methanol

Chemical Property:

• PSA: 46.26000
• LogP: 1.32010
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 149.047678466
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

FURO[3,2-C]PYRIDINE-7-METHANOL 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC2=C(C=NC=C21)CO

Technology Process of Furo[3,2-C]pyridine-7-methanol

There total 6 articles about Furo[3,2-C]pyridine-7-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

furo[3,2-c]pyridine-7-carboxylic acid (603302-86-9) → (furo[3,2-c]pyridin-7-yl)methanol (603302-91-6)

Guidance literature:

furo[3,2-c]pyridine-7-carboxylic acid; With borane-THF; In tetrahydrofuran; for 1.5h;

With hydrogenchloride; water; In tetrahydrofuran; for 0.25h;

With ammonia; water; In tetrahydrofuran;

Reference yield:

furo[3,2-c]pyridine-7-carbonitrile (603302-76-7) → (furo[3,2-c]pyridin-7-yl)methanol (603302-91-6)

Guidance literature:

furo[3,2-c]pyridine-7-carbonitrile; With ammonium hydroxide; at 150 ℃;

With borane-THF;

DOI:10.1016/j.bmcl.2004.12.063

Reference yield:

5H-furo[3,2-c]pyridin-4-one (26956-43-4) → (furo[3,2-c]pyridin-7-yl)methanol (603302-91-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 75 percent / NBS

2.1: 50 percent / POBr₃

3.1: 75 percent / Pd(PPh₃)4; HCOONa

4.1: 94 percent / CuI / dimethylformamide

5.1: NH₄OH / 150 °C

5.2: BH₃*THF

With ammonium hydroxide; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; phosphorus(V) oxybromide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.12.063

upstream raw materials:

furo[3,2-c]pyridine-7-carbonitrile

5H-furo[3,2-c]pyridin-4-one

7-bromofuro[3,2-c]pyridine

4,7-dibromofuro[3,2-c]pyridine