BZL-SER(TBU)-OME HCL

Base Information

• Chemical Name: BZL-SER(TBU)-OME HCL
• CAS No.: 670278-82-7
• Molecular Formula: C15H23NO3
• Molecular Weight: 265.353
• Hs Code.: 2922509090
• Mol file: 670278-82-7.mol

Synonyms:N-BENZYL-O-T-BUTYL-L-SERINE METHYL ESTER HYDROCHLORIDE;N-BENZYL-O-TERT-BUTYL-L-SERINE METHYL ESTER HYDROCHLORIDE;BZL-L-SER(TBU)-OME;BZL-L-SER(TBU)-OME HCL;BZL-SER(TBU)-OME HCL;BENZYL-O-T-BUTYL-SERINE METHYL ESTER HYDROCHLORIDE;BENZYL-L-SERINE TERT-BUTYL METHYL ESTER HYDROCHLORIDE;N-.ALPHA.-BENZYL-O-TERT-BUTYL-L-SERINE METHYL ESTER HYDROCHLORIDE

Chemical Property of BZL-SER(TBU)-OME HCL

Chemical Property:

• PSA: 47.56000
• LogP: 3.32580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

Benzyl-O-tert-butyl-L-serineMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BZL-SER(TBU)-OME HCL

There total 4 articles about BZL-SER(TBU)-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

benzaldehyde (100-52-7) + O-tert-butyl-L-serine methyl ester hydrochloride (17114-97-5) → (S)-methyl 2-(benzylamino)-3-(tert-butoxy)propanoate (670278-82-7)

Guidance literature:

benzaldehyde; O-tert-butyl-L-serine methyl ester hydrochloride; With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 48h;

With water; sodium hydrogencarbonate; Cooling with ice;

Reference yield:

C15H21NO3 → (S)-methyl 2-(benzylamino)-3-(tert-butoxy)propanoate (670278-82-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1039/c4cc03660c

Reference yield:

benzaldehyde (100-52-7) → (S)-methyl 2-(benzylamino)-3-(tert-butoxy)propanoate (670278-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 1.5 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; In methanol;

DOI:10.1039/c4cc03660c

upstream raw materials:

benzaldehyde

O-tert-butyl-L-serine methyl ester hydrochloride

O-tert-butyl-L-serine methyl ester

Downstream raw materials:

(S)-2-allyl-4-benzyl-5-(hydroxymethyl)-1,2,4-triazinane-3,6-dione

(S)-2-benzyl-3-(hydroxymethyl)-2,3,8,9-tetrahydropyridazino[1,2-a][1,2,4]triazine-1,4-dione

C₂₄H₃₇N₃O₆

Refernces

• 1、 -. "IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE". Page/Page column 74. . Retrieved 2011/11/07.