N-[(4-amino-2-methyl-5-pyrimidyl)methyl]thioformamide

Base Information

• Chemical Name: N-[(4-amino-2-methyl-5-pyrimidyl)methyl]thioformamide
• CAS No.: 31375-20-9
• Molecular Formula: C7H10 N4 S
• Molecular Weight: 182.249
• Hs Code.: 2933599090
• Mol file: 31375-20-9.mol

Synonyms:Formamide,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]thio- (6CI,7CI,8CI)

Chemical Property of N-[(4-amino-2-methyl-5-pyrimidyl)methyl]thioformamide

Chemical Property:

• Vapor Pressure: 1.92E-05mmHg at 25°C
• Melting Point: 189-190 °C
• Boiling Point: 362.5°Cat760mmHg
• PKA: 10.70±0.70(Predicted)
• Flash Point: 173.1°C
• PSA: 103.69000
• Density: 1.29g/cm³
• LogP: 0.75540

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(4-amino-2-methyl-5-pyrimidyl)methyl]thioformamide

There total 18 articles about N-[(4-amino-2-methyl-5-pyrimidyl)methyl]thioformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid ethyl ester (14273-42-8) → 4-Amino-2-methyl-5-thioformamidomethylpyrimidin (31375-20-9)

Guidance literature:

Multi-step reaction with 5 steps

1: POCl₃ / folgendes Erhitzen mit aethanol.NH₃

2: N₂H₄+H₂O

3: KNO₂; water; HCl

5: toluene; P₂S₅

With hydrogenchloride; potassium nitrite; tetraphosphorus decasulfide; water; hydrazine hydrate; toluene; trichlorophosphate;

Reference yield:

5-(aminomethyl)-2-methylpyrimidin-4-amine (95-02-3) + potassium dithioformate (30962-16-4) → 4-Amino-2-methyl-5-thioformamidomethylpyrimidin (31375-20-9)

Guidance literature:

With water;

Reference yield:

(4-amino-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester (220895-93-2) → 4-Amino-2-methyl-5-thioformamidomethylpyrimidin (31375-20-9)

Guidance literature:

Multi-step reaction with 4 steps

1: N₂H₄+H₂O

2: KNO₂; water; HCl

4: toluene; P₂S₅

With hydrogenchloride; potassium nitrite; tetraphosphorus decasulfide; water; hydrazine hydrate; toluene;

upstream raw materials:

5-(aminomethyl)-2-methylpyrimidin-4-amine

thiocarboxamide

potassium dithioformate

2-methyl-4-amino-5-formylaminomethylpyrimidine

Downstream raw materials:

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chloro-ethyl)-4-methyl-thiazolium; chloride-hydrochloride

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-phenyl-thiazolium; chloride-hydrochloride

Thiamine hydrochloride