Chemical Property of Thiamine Hydrochloride
Chemical Property:
- Appearance/Colour:White crystalline powder
- Melting Point:250 °C (dec.)(lit.)
- Refractive Index:1.6000 (estimate)
- PKA:pKa 4.8 (Uncertain);9.0 (Uncertain)
- Flash Point:100oC
- PSA：104.15000
- Density:1.401 g/cm3
- LogP:-1.00510
- Storage Temp.:2-8°C
- Sensitive.:Light Sensitive & Hygroscopic
- Solubility.:H2O: 0.1 g/mL at 20 °C, clear, colorless
- Water Solubility.:1 g/mL
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:4
- Exact Mass:336.0578378
- Heavy Atom Count:20
- Complexity:269
- Purity/Quality:
-
99% *data from raw suppliers
Thiamine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi,T,F
- Statements:
36/37/38-39/23/24/25-23/24/25-11
- Safety Statements:
22-24/25-37/39-26-36-45-36/37-16-7
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Biological Agents -> Vitamins and Derivatives
- Canonical SMILES:CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO.Cl.[Cl-]
- Recent ClinicalTrials:Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock.
- Recent EU Clinical Trials:MULTI-TECHNICAL TEST ON THE USE OF COMBINED THERAPY OF THEMIN AND BIOTINE IN PATIENTS WITH HUNTINGTON'S DISEASE
-
Description
Thiamine Hydrochloride is the hydrochloride salt form of thiamine (vitamin B1), a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Vitamin B1 helps prevent various health problems including heart damage.
Thiamine hydrochloride is used to prevent and treat thiamine deficiency states, which may occur as a result of inadequate nutrition or intestinal malabsorption. It is also used for the treatment of Wernicke-Korsakoff syndrome, beriberi and thiamine deficiency related to chronic alcoholism. Thiamine hydrochloride is used as a food additive to add brothy/meaty flavor to gravies or soups. It is used also as a food supplement and flavoring ingredient with a bitter taste. In 1912, Cashmir Funk isolated thiamine from rice husks and
coined the term ‘vitamine’ because it was required for life
(‘vita’) and because thiamine contained nitrogen (‘amine’).
Thiamine, formerly known as B1, is water soluble. Thiamine is
a vital cofactor for enzymes and coenzymes of glycolysis, the
Kreb’s cycle, the pentose phosphate pathway. Thiamine is also
involved in the biosynthesis of the neurotransmitters acetylcholine
and gamma-aminobutyric acid and in nerve
propagation.
-
Uses
Thiamine is the water-soluble vitamin b1, required for normal digestion and functioning of nerve tissues and in the prevention of beriberi. It also acts as a coenzyme in the metabolism of carbohydrates. During processing, the higher and longer the heating period, the greater the loss. The loss is reduced in the presence of acid. Thiamine hydrochloride and thiamine mononitrate are two available forms. The mononitrate form is less hygroscopic and more stable than the hydrochloride form, making it suitable for use in beverage powders. It is used in enriched flour and is found as thiamine mononitrite in frozen egg substitute and crackers. Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products
, vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t
o neurological impairment, bariberi, Wernicke-Korsakoff syndrome. A cofactor required for oxidation of carbohydrates and for the synthesis of ribose.
