4-Cyclohexylpiperidine hydrochloride

Base Information

• Chemical Name: 4-Cyclohexylpiperidine hydrochloride
• CAS No.: 60601-62-9
• Molecular Formula: C₁₁H₂₁N*ClH
• Molecular Weight: 203.755
• Hs Code.: 2933399090
• European Community (EC) Number: 691-829-2
• DSSTox Substance ID: DTXSID20589983
• Mol file: 60601-62-9.mol

Synonyms:4-Cyclohexylpiperidine hydrochloride;60601-62-9;4-CYCLOHEXYLPIPERIDINE HCL;4-cyclohexylpiperidine;hydrochloride;4-Cyclohexylpiperidine, HCl;SCHEMBL7244618;DTXSID20589983;4-Cyclohexylpiperidinehydrochloride;VERIFEZQOCIVJD-UHFFFAOYSA-N;4-cyclohexyl-piperidine hydrochloride;AR1718;MFCD05863876;AKOS024015275;SB43313;AS-45194;DB-324983;CS-0200227;EN300-262731;4-cyclohexylpiperidine hydrochloride, AldrichCPR;4-Cyclohexylpiperidine--hydrogen chloride (1/1);A924085

Chemical Property of 4-Cyclohexylpiperidine hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 3.69710
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 203.1440774
• Heavy Atom Count: 13
• Complexity: 121

Purity/Quality:

95-99% ^*data from raw suppliers

4-Cyclohexylpiperidinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C2CCNCC2.Cl

Technology Process of 4-Cyclohexylpiperidine hydrochloride

There total 8 articles about 4-Cyclohexylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

p-phenylpyridine (939-23-1) → 4-cyclohexenylpiperidine hydrochloride (60601-62-9)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In methanol; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201900399

Reference yield: 92.0%

4-cyclohexylpyridine (13669-35-7) → 4-cyclohexenylpiperidine hydrochloride (60601-62-9)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

DOI:10.1002/ejoc.201900399

Reference yield: 91.0%

1-(3-bromopyridin-4-yl)cyclohexanol → 4-cyclohexenylpiperidine hydrochloride (60601-62-9)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 80 ℃; for 18h; under 45004.5 Torr; Autoclave;

DOI:10.1002/ejoc.201900450

upstream raw materials:

p-phenylpyridine

picoline

1,5-dibromo-pentane

4-cyclohexylpyridine

Refernces

• 1、 Subota, Andrii I.,Lutsenko, Anton O.,Vashchenko, Bohdan V.,Volochnyuk, Dmitriy M.,Levchenko, Vitalina,Dmytriv, Yurii V.,Rusanov, Eduard B.,Gorlova, Alina O.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.. "Scalable and Straightforward Synthesis of All Isomeric (Cyclo)alkylpiperidines". . p. 3636 - 3648. Retrieved 2019/06/13.
• 2、 Berardi, Francesco,Abate, Carmen,Ferorelli, Savina,Uricchio, Vincenzo,Colabufo, Nicola A.,Niso, Mauro,Perrone, Roberto. "Exploring the importance of piperazine N-atoms for σ2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5- methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-propyl]piperazine (PB28)". supporting information; experimental part. p. 7817 - 7828. Retrieved 2010/04/30.