N-CBZ-L-ALANYL-D-1-AMINOETHYLPHOSPHONIC ACID DIMETHYL ESTER)

Base Information

Chemical Name:N-CBZ-L-ALANYL-D-1-AMINOETHYLPHOSPHONIC ACID DIMETHYL ESTER)
CAS No.:60668-36-2
Molecular Formula:C15H23N2O6P
Molecular Weight:358.33
Hs Code.:
Mol file:60668-36-2.mol

Synonyms:N-CBZ-L-ALANYL-D-1-AMINOETHYLPHOSPHONIC ACID DIMETHYL ESTER);dimethyl N-carbobenzyloxy-L-alanylaminoethylphosphonate

Suppliers and Price of N-CBZ-L-ALANYL-D-1-AMINOETHYLPHOSPHONIC ACID DIMETHYL ESTER)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-CBZ-L-ALANYL-D-1-AMINOETHYLPHOSPHONIC ACID DIMETHYL ESTER)

Chemical Property:

PSA：119.75000
LogP:2.94810

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-CBZ-L-ALANYL-D-1-AMINOETHYLPHOSPHONIC ACID DIMETHYL ESTER)

There total 2 articles about N-CBZ-L-ALANYL-D-1-AMINOETHYLPHOSPHONIC ACID DIMETHYL ESTER) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: dimethyl l-benzylaminoethyl phosphonate hydrochloride

: 65037-50-5
dimethyl l-aminoethylphosphonate hydrochloride

: 60668-36-2
dimethyl(1S)-1-[(N-benzyloxycarbonyl-L-alanyl)amino]-ethylphosphonate

Guidance literature:: With triethylamine; In N-methyl-acetamide; methanol; palladium;

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 79646-31-4
(1-Benzylamino-ethyl)-phosphonic acid dimethyl ester; hydrochloride

: 67739-69-9
[(R)-1-((S)-2-Benzyloxycarbonylamino-propionylamino)-ethyl]-phosphonic acid dimethyl ester

: 60668-36-2
dimethyl(1S)-1-[(N-benzyloxycarbonyl-L-alanyl)amino]-ethylphosphonate

Guidance literature:: With hydrogen; pyrographite; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; Multistep reaction. Yields of byproduct given; 1.) CH₂, RT, 1 atm, 3 h, 2.) CH₂Cl₂, 0 deg C, overnight;
DOI:10.1021/jm00151a005

Reference yield:

: 60668-36-2
dimethyl(1S)-1-[(N-benzyloxycarbonyl-L-alanyl)amino]-ethylphosphonate

: {(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-propionylamino]-ethyl}-phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: conc. aq. HCl / CH₂Cl₂ / 24 h

2: NaHCO₃ / H₂O; ethanol

With hydrogenchloride; sodium hydrogencarbonate; In ethanol; dichloromethane; water;
DOI:10.1021/jm00151a005