Technology Process of 2-Piperidinecarboxylicacid,5,5-difluoro-,(2S)-(9CI)
There total 5 articles about 2-Piperidinecarboxylicacid,5,5-difluoro-,(2S)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6,6-difluoro-3,3-bis-trifluoromethyl-tetrahydro-oxazolo[3,4-a]pyridin-1-one;
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
With
methyloxirane;
In
1,4-dioxane;
Further stages.;
DOI:10.1016/j.tetlet.2003.12.038
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 76 percent / dimethylsulfoxide / 20 °C
2.1: isobutyl chloroformate; N-methyl morpholine / -15 °C
2.2: 61 percent / 0 °C
3.1: 44 percent / dirhodium tetraacetate / CHCl3 / Heating
4.1: 59 percent / diethylaminosulfur trifluoride / CH2Cl2 / -78 °C
5.1: aq. HCl / dioxane / 20 °C
5.2: 61 percent / propene oxide / dioxane
With
4-methyl-morpholine; hydrogenchloride; diethylamino-sulfur trifluoride; isobutyl chloroformate;
dirhodium tetraacetate;
In
1,4-dioxane; dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2003.12.038
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isobutyl chloroformate; N-methyl morpholine / -15 °C
1.2: 61 percent / 0 °C
2.1: 44 percent / dirhodium tetraacetate / CHCl3 / Heating
3.1: 59 percent / diethylaminosulfur trifluoride / CH2Cl2 / -78 °C
4.1: aq. HCl / dioxane / 20 °C
4.2: 61 percent / propene oxide / dioxane
With
4-methyl-morpholine; hydrogenchloride; diethylamino-sulfur trifluoride; isobutyl chloroformate;
dirhodium tetraacetate;
In
1,4-dioxane; dichloromethane; chloroform;
DOI:10.1016/j.tetlet.2003.12.038
