3,8-Diazabicyclo[3.2.1]octane-2-carboxylicacid,4-oxo-,methylester,(1R,2R,5S)-(9CI)

Base Information

Chemical Name:3,8-Diazabicyclo[3.2.1]octane-2-carboxylicacid,4-oxo-,methylester,(1R,2R,5S)-(9CI)
CAS No.:676148-40-6
Molecular Formula:C8H12N2O3
Molecular Weight:184.19
Hs Code.:
Mol file:676148-40-6.mol

Synonyms:3,8-Diazabicyclo[3.2.1]octane-2-carboxylicacid,4-oxo-,methylester,(1R,2R,5S)-(9CI);MMETHYL (2R)-4-OXO-3,8-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXYLATE

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Chemical Property of 3,8-Diazabicyclo[3.2.1]octane-2-carboxylicacid,4-oxo-,methylester,(1R,2R,5S)-(9CI)

Chemical Property:

PSA：67.43000
LogP:-0.56400

Purity/Quality:

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Technology Process of 3,8-Diazabicyclo[3.2.1]octane-2-carboxylicacid,4-oxo-,methylester,(1R,2R,5S)-(9CI)

There total 5 articles about 3,8-Diazabicyclo[3.2.1]octane-2-carboxylicacid,4-oxo-,methylester,(1R,2R,5S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: (S)-5-[1-Methoxycarbonyl-1-nitro-meth-(Z)-ylidene]-pyrrolidine-2-carboxylic acid methyl ester

: 676148-40-6
4-oxo-3,8-diazabicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 96h; under 2327.23 Torr;
DOI:10.1016/j.tetlet.2003.12.031

Reference yield:

: methyl (S)-5-(2-methoxy-1-nitro-2-oxoethylidene)pyrrolidine-2-carboxylate

: 676148-40-6
methyl (1R,2R,5S)-4-oxo-3,8-diazabicyclo[3.2.1]octane-2-carboxylate

Guidance literature:: With palladium hydroxide, 20 wt% on carbon; hydrogen; In methanol; for 72h; under 2327.23 Torr;

Reference yield:

: 137131-35-2
5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester

: 676148-40-6
4-oxo-3,8-diazabicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 30 h / 60 °C

2: 52 percent / H₂ / Pd/C / methanol / 96 h / 20 °C / 2327.23 Torr

With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.tetlet.2003.12.031