6-chloroquinazoline

Base Information

• Chemical Name: 6-chloroquinazoline
• CAS No.: 700-78-7
• Molecular Formula: C₈H₅ClN₂
• Molecular Weight: 164.594
• Hs Code.: 2933990090
• Mol file: 700-78-7.mol

Synonyms:6-Chloroquinazoline;6-chloroquinazoline;

Chemical Property of 6-chloroquinazoline

Chemical Property:

• Vapor Pressure: 0.00624mmHg at 25°C
• Melting Point: 142-143 °C
• Refractive Index: 1.662
• Boiling Point: 281 °C at 760 mmHg
• PKA: 3.61±0.26(Predicted)
• Flash Point: 150.6 °C
• PSA: 25.78000
• Density: 1.349 g/cm³
• LogP: 2.28320
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-chloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloroquinazoline

There total 13 articles about 6-chloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-(aminomethyl)-4-chloroaniline (108047-39-8) + orthoformic acid triethyl ester (122-51-0) → 6-chloroquinazoline (700-78-7)

Guidance literature:

In ethanol; for 6h; Heating;

Reference yield: 42.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 2-amino-5-chlorobenzaldehyde (20028-53-9) → 6-chloroquinazoline (700-78-7)

Guidance literature:

With tert.-butylhydroperoxide; N-iodo-succinimide; ammonia; In water; at 120 ℃; for 4h;

DOI:10.1002/anie.201203880

Reference yield: 32.0%

N,N,N,N,-tetramethylethylenediamine (110-18-9) + 2-amino-5-chlorobenzaldehyde (20028-53-9) → 6-chloroquinazoline (700-78-7)

Guidance literature:

With iodine; oxygen; ammonium chloride; In dimethyl sulfoxide; at 120 ℃; for 20h; under 760.051 Torr;

DOI:10.1021/acs.joc.5b00474

upstream raw materials:

6-amino-quinazoline

N,N'-(5-chloro-2-nitro-benzylidene)-bis-formamide

2-(aminomethyl)-4-chloroaniline

orthoformic acid triethyl ester

Downstream raw materials:

6-ethenylquinazoline

quinazoline-6-carbaldehyde

Refernces

• 1、 Yan, Yizhe,Zhang, Yonghui,Feng, Chengtao,Zha, Zhenggen,Wang, Zhiyong. "Selective iodine-catalyzed intermolecular oxidative amination of C(sp 3)-H bonds with ortho-carbonyl-substituted anilines to give quinazolines". supporting information; experimental part. p. 8077 - 8081. Retrieved 2012/08/29.
• 2、 -. "THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS". Page/Page column 46. . Retrieved 2008/06/13.