Hydrazine, [1-(4-fluorophenyl)ethyl]-

Base Information

• Chemical Name: Hydrazine, [1-(4-fluorophenyl)ethyl]-
• CAS No.: 701-48-4
• Molecular Formula: C8H11FN2
• Molecular Weight: 154.187
• Mol file: 701-48-4.mol

Synonyms:Hydrazine, [1-(4-fluorophenyl)ethyl]-

Chemical Property of Hydrazine, [1-(4-fluorophenyl)ethyl]-

Chemical Property:

• PSA: 38.05000
• LogP: 2.44120

Purity/Quality:

99% ^*data from raw suppliers

1-(1-(4-fluorophenyl)ethyl)hydrazine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydrazine, [1-(4-fluorophenyl)ethyl]-

There total 3 articles about Hydrazine, [1-(4-fluorophenyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

→ ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + α-methyl-4-fluorobenzylhydrazine (701-48-4)

Guidance literature:

Reference yield:

1-(4-Fluor-α-methyl-benzyl)-2-ethoxycarbonyl-hydrazin (1478-87-1) → α-methyl-4-fluorobenzylhydrazine (701-48-4)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → α-methyl-4-fluorobenzylhydrazine (701-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) iPrOH, (ii) H₂, PtO₂

2: KOH / ethanol / Heating

With potassium hydroxide; In ethanol;

upstream raw materials:

1-(4-Fluor-α-methyl-benzyl)-2-ethoxycarbonyl-hydrazin

1-(4-fluorophenyl)ethanone

Refernces

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

10.1021/acs.orglett.1c01720

The study presents an efficient method for the trifluoromethylation of benzoic acids using TMSCF3 (trimethylsilyl trifluoromethane) to produce aryl trifluoromethyl ketones. The reaction involves anhydrides as in situ activating reagents, with trifluoroacetic anhydride (TFAA) and 4-dimethylaminopyridine (DMAP) playing crucial roles in activating the carboxylic acids and facilitating nucleophilic addition. CsF (cesium fluoride) is used to enhance the yield of the desired products. The reaction is conducted in PhOMe (anisole) solvent under nitrogen at 120 °C for 15 hours. The study demonstrates a wide substrate scope, including various carboxylic acids with different functional groups, and shows high functional group tolerance. Notably, bioactive molecules such as adapalin, probenecid, and telmisartan can also be trifluoromethylated using this method, highlighting its potential in drug design and development. The reaction conditions are relatively mild, and the process is scalable, making it a practical and environmentally benign approach for synthesizing aryl trifluoromethyl ketones.

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