5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID
• CAS No.: 677702-22-6
• Molecular Formula: C8H5IN2O
• Molecular Weight: 288.04
• Mol file: 677702-22-6.mol

Synonyms:5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-IODO-3-(1H)INDAZOLE CARBOXALDEHYDE;5-IODO-3-(1H)INDAZOLE CARBOXYLIC ACID;5-Iodo-3-(1H)indazolecarboxyaldehyde;5-IODOINDAZOLE-3-CARBOXYALDEHYDE

Chemical Property of 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 8.66E-08mmHg at 25°C
• Refractive Index: 1.824
• Boiling Point: 435.6°C at 760 mmHg
• PKA: 10.91±0.40(Predicted)
• Flash Point: 217.2°C
• PSA: 45.75000
• Density: 2.111g/cm³
• LogP: 1.98000
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Iodo-1H-indazole-3-carbaldehyde 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID

There total 3 articles about 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-iodo-1H-indole (16066-91-4) → 5-iodo-1H-indazole-3-carboxaldehyde (677702-22-6)

Guidance literature:

With hydrogenchloride; water; sodium nitrite; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 10h; Inert atmosphere;

DOI:10.1039/c8ra01546e

Reference yield: 80.0%

3-hydroxymethyl-5-iodo-1H-indazole (705264-87-5) → 5-iodo-1H-indazole-3-carboxaldehyde (677702-22-6)

Guidance literature:

With manganese(IV) oxide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;

Reference yield: 58.2%

5-iodo-N-methoxy-N-methyl-1H-indazole-3-carboxamide (351457-14-2) → 5-iodo-1H-indazole-3-carboxaldehyde (677702-22-6)

Guidance literature:

5-iodo-N-methoxy-N-methyl-1H-indazole-3-carboxamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sodium hydrogen sulfate; water; In tetrahydrofuran; ethyl acetate;

upstream raw materials:

5-iodo-1H-indole

3-hydroxymethyl-5-iodo-1H-indazole

5-iodo-N-methoxy-N-methyl-1H-indazole-3-carboxamide

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