705264-87-5

Usage

Uses

Used in Medicinal Chemistry:
(5-iodo-1H-indazol-3-yl)Methanol is used as a chemical intermediate for the synthesis of various indazole-based pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Pharmaceutical Research:
(5-iodo-1H-indazol-3-yl)Methanol is used as a research tool for studying the biological activities of indazole derivatives. Its potential anticancer, antibacterial, and antifungal properties make it a valuable compound for investigating novel therapeutic agents and understanding their mechanisms of action.
Used in Organic Synthesis:
(5-iodo-1H-indazol-3-yl)Methanol is used as a precursor in the preparation of other functionalized indazole derivatives. Its iodo and methanol groups can be further modified or used as starting points for the synthesis of more complex molecules with specific properties and applications.
Used in Chemical Industry:
(5-iodo-1H-indazol-3-yl)Methanol may find applications in the chemical industry as a building block for the development of new materials, catalysts, or other specialty chemicals. Its unique structure and functional groups can be exploited to create innovative products with diverse applications.

Upstream product

• 1079-47-6 methyl 5-iodo-1H-indazole-3-carboxylate 
• 1207-38-1 5-Iod-3-ethoxycarbonyl-indazol 

Downstream Products

• 705264-88-6 (5-iodo-1H-indazol-3-ylmethyl)-triphenylphosphonium bromide 
• 677702-22-6 5-iodo-1H-indazole-3-carboxaldehyde 

Relevant academic research and scientific papers

Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.

JNK INHIBITOR

The present invention provides a JNK inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I) [wherein R1 represents substituted or unsubstituted aryl or the like and R2 represents a hydrogen a