1-BOC-4-(3-FLUORO-PHENYLAMINO)-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-(3-FLUORO-PHENYLAMINO)-PIPERIDINE
• CAS No.: 679409-18-8
• Molecular Formula: C16H23FN2O2
• Molecular Weight: 294.369
• Mol file: 679409-18-8.mol

Synonyms:1-BOC-4-(3-FLUORO-PHENYLAMINO)-PIPERIDINE

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Chemical Property of 1-BOC-4-(3-FLUORO-PHENYLAMINO)-PIPERIDINE

Chemical Property:

• PSA: 41.57000
• LogP: 3.64800
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(3-FLUORO-PHENYLAMINO)-PIPERIDINE

There total 2 articles about 1-BOC-4-(3-FLUORO-PHENYLAMINO)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

meta-fluoroaniline (372-19-0) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-((3-fluorophenyl)amino)piperidine-1-carboxylate (679409-18-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2010.10.042

Reference yield:

C16H21FN2O2 → tert-butyl 4-((3-fluorophenyl)amino)piperidine-1-carboxylate (679409-18-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1016/j.bmcl.2008.10.072

Reference yield: 100.0%

tert-butyl 4-((3-fluorophenyl)amino)piperidine-1-carboxylate (679409-18-8) → N-(3-fluorophenyl)-4-piperidinamine (886506-63-4)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 60 ℃;

DOI:10.1016/j.bmcl.2008.10.072

upstream raw materials:

meta-fluoroaniline

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

N-(3-fluorophenyl)-4-piperidinamine

tert-butyl 4-{(3-fluorophenyl)[(6-methylpyridin-3-yl)carbamoyl]amino}piperidine-1-carboxylate

1,1-dimethylethyl 4-{(3-fluorophenyl)[({1-[(methyloxy)methyl]-1H-indazol-6-yl}amino)carbonyl]amino}-1-piperidinecarboxylate

1,1-dimethylethyl 4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinecarboxylate