(R)-(-)-S-Methyl-S-phenylsulfoximine

Base Information

• Chemical Name: (R)-(-)-S-Methyl-S-phenylsulfoximine
• CAS No.: 60933-65-5
• Molecular Formula: C7H9NOS
• Molecular Weight: 155.221
• Hs Code.: 2925290090
• Mol file: 60933-65-5.mol

Synonyms:(R)-(-)-S-Methyl-S-phenylsulphoximine;Imino-methyl-oxo-phenyl-$l^{6}-sulfane;(S-Methylsulfonimidoyl)benzene;

Chemical Property of (R)-(-)-S-Methyl-S-phenylsulfoximine

Chemical Property:

• Melting Point: 29-31 °C
• Boiling Point: 237.8 °C at 760 mmHg
• Flash Point: 97.6 °C
• PSA: 49.30000
• Density: 1.14 g/cm³
• LogP: 2.68750
• Sensitive.: Hygroscopic

Purity/Quality:

98%Min ^*data from raw suppliers

(R)?-?(-?)?-?S-?Methyl-?S-?phenylsulfoximine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: (R)-(-)-S-Methyl-S-phenylsulfoximine is used as chiral ligands.

Technology Process of (R)-(-)-S-Methyl-S-phenylsulfoximine

There total 71 articles about (R)-(-)-S-Methyl-S-phenylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C10H16O4S*C7H9NOS (7044-59-9) → (S)-S-methyl-S-phenylsulfoximine (4381-25-3,33903-50-3,60933-65-5,81162-81-4)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

DOI:10.1002/anie.202016968

Reference yield: 94.0%

(S)-S-methyl-S-phenyl-N-(((S)-2,2,2-trichloro-1-phenylethoxy)carbonyl)sulfoximine → (R)-S-methyl-S-phenylsulfoximine (60933-65-5)

Guidance literature:

With acetic acid; zinc; at 23 ℃; for 8h;

DOI:10.1002/anie.201402961

Reference yield: 93.0%

(S)-methylphenylsulfoxide (1193-82-4,4850-71-9,18453-46-8,20696-08-6) → (S)-S-methyl-S-phenylsulfoximine (4381-25-3,33903-50-3,60933-65-5,81162-81-4)

Guidance literature:

With 1,10-Phenanthroline; O-(4-nitrobenzoyl)hydroxylammonium trifluoromethanesulfonate; iron(II) sulfate; In acetonitrile; at 30 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201710498

upstream raw materials:

S-methyl-S-phenylsulfoximine

S-Methyl-S-phenyl-N-carboethoxysulfoximid

methyl-phenyl-thioether

racemic methyl phenyl sulfoxide

Downstream raw materials:

(-)-(R)-Methylphenyloxosulfonium-bis-(methoxycarbonyl)-methylid

Refernces

• 1、 Alharbi, Haifa,Elsherbini, Mohamed,Karam, Fatemah,Osi, Arnaud,Wirth, Thomas. "Sulfur-Based Chiral Iodoarenes: An Underexplored Class of Chiral Hypervalent Iodine Reagents". . . Retrieved 2021/06/21.
• 2、 Argent, Stephen P.,Lewis, William,Mendon?a Matos, Priscilla,Moore, Jonathan c.,Stockman, Robert A.. "General Method for the Asymmetric Synthesis of N-H Sulfoximines via C-S Bond Formation". supporting information. . Retrieved 2020/03/30.